Um Yoo Jin, Kim Yejin, Chang Yoosoo, Jung Hyun-Suk, Cho In Young, Jeon Sang Won, Ryu Seungho
Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of Family Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Gyeonggi-do, Republic of Korea.
Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Institute of Medical Research, School of Medicine, Sungkyunkwan University, Suwon, Republic of Korea.
J Affect Disord. 2023 May 1;328:64-71. doi: 10.1016/j.jad.2023.02.031. Epub 2023 Feb 14.
The longitudinal relationship between sleep duration, sleep quality, and their changes with the risk of depressive symptoms is unclear. We examined the association between sleep duration, sleep quality, and their changes with incident depressive symptoms.
A total of 225,915 Korean adults without depression at baseline with a mean age of 38.5 years were followed for an average of 4.0 years. Sleep duration and quality were assessed using the Pittsburgh Sleep Quality Index. The presence of depressive symptoms was assessed using the Center for Epidemiologic Studies Depression scale. Flexible parametric proportional hazard models were used to determine hazard ratios (HRs) and 95 % confidence intervals (CIs).
In total, 30,104 participants with incident depressive symptoms were identified. Multivariable-adjusted HRs (95 % CIs) for incident depression comparing sleep durations of ≤5, 6, 8, and ≥9 h with 7 h were 1.15 (1.11-1.20), 1.06 (1.03-1.09), 0.99 (0.95-1.03), and 1.06 (0.98-1.14), respectively. A similar trend was observed in patients with poor sleep quality. Compared with participants with persistently good sleep quality, participants with persistently poor sleep quality or who developed poor sleep quality were associated with the risk of incident depressive symptoms [HRs (95 % CIs) of 2.13 (2.01-2.25) and 1.67 (1.58-1.77), respectively].
Sleep duration was assessed using self-reported questionnaire and the study population may not reflect general population.
Sleep duration, sleep quality and their changes were independently associated with incident depressive symptoms in young adults, suggesting that inadequate sleep quantity and quality play a role in depression risk.
睡眠时间、睡眠质量及其变化与抑郁症状风险之间的纵向关系尚不清楚。我们研究了睡眠时间、睡眠质量及其变化与新发抑郁症状之间的关联。
共有225,915名基线时无抑郁的韩国成年人，平均年龄38.5岁，随访平均4.0年。使用匹兹堡睡眠质量指数评估睡眠时间和质量。使用流行病学研究中心抑郁量表评估抑郁症状的存在情况。采用灵活的参数比例风险模型确定风险比（HRs）和95%置信区间（CIs）。
总共确定了30,104名有新发抑郁症状的参与者。将睡眠时间≤5小时、6小时、8小时和≥9小时与7小时相比，新发抑郁的多变量调整后HRs（95% CIs）分别为1.15（1.11 - 1.20）、1.06（1.03 - 1.09）、0.99（0.95 - 1.03）和1.06（0.98 - 1.14）。睡眠质量差的患者也观察到类似趋势。与睡眠质量持续良好的参与者相比，睡眠质量持续差或出现睡眠质量差的参与者与新发抑郁症状风险相关[HRs（95% CIs）分别为2.13（范围2.01 - 2.25）和1.67（范围1.58 - 1.77）]。
睡眠时间通过自我报告问卷进行评估，且研究人群可能无法反映一般人群。
睡眠时间、睡眠质量及其变化与年轻人新发抑郁症状独立相关，表明睡眠数量和质量不足在抑郁风险中起作用。
