新型有机污染物吉非贝齐的生物降解：机理、动力学及途径建模
Biodegradation of emerging organic pollutant gemfibrozil: Mechanism, kinetics and pathway modelling.
作者信息
Kamal Neha, Sindhu Raveendran, Chaturvedi Bhargava Preeti
机构信息
Aquatic Toxicology Laboratory, Environmental Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, M.G. Marg, Lucknow 226001, Uttar Pradesh, India.
Department of Food Technology, T K M Institute of Technology, Kollam 691505, Kerala, India.
出版信息
Bioresour Technol. 2023 Apr;374:128749. doi: 10.1016/j.biortech.2023.128749. Epub 2023 Feb 14.
The increasing population has raised the demand for pharmaceutical and personal care products to maintain a good health. Gemfibrozil (GEM), is extensively used as a lipid regulator and is frequently detected in wastewater treatment systems and poses deleterious health and ecological effects. Hence, the current study employing Bacillus sp. N2 reports the degradation of gemfibrozil via co-metabolism in 15 days. The study reported 86 % degradation with GEM (20 mgL) using sucrose (150 mgL) as a co-substrate; as compared to 42 % without a co-substrate. Further, time-profiling studies of metabolites revealed significant demethylation and decarboxylation reactions during degradation that leads to formation of six (M1, M2, M3, M4, M5, M6) metabolites as by-products. Based on the LC-MS analysis a potential degradation pathway for GEM by Bacillus sp. N2 was proposed. The degradation of GEM has not been reported so far and the study envisages eco-friendly approach to tackle pharmaceutical- active- compounds.
不断增长的人口增加了对药品和个人护理产品的需求，以维持良好的健康状况。吉非贝齐（GEM）被广泛用作脂质调节剂，并且经常在废水处理系统中被检测到，对健康和生态产生有害影响。因此，当前这项使用芽孢杆菌属N2的研究报告了吉非贝齐在15天内通过共代谢作用的降解情况。该研究报告称，以蔗糖（150 mg/L）作为共底物时，吉非贝齐（20 mg/L）的降解率为86%；相比之下，没有共底物时降解率为42%。此外，对代谢物的时间进程研究表明，降解过程中发生了显著的去甲基化和脱羧反应，产生了六种（M1、M2、M3、M4、M5、M6）代谢物作为副产物。基于液相色谱-质谱分析，提出了芽孢杆菌属N2对吉非贝齐的潜在降解途径。目前尚未见关于吉非贝齐降解的报道，该研究设想了一种生态友好的方法来处理药物活性化合物。
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