细胞外囊泡在椎间盘退变中的作用进展
[Advances in the role of extracellular vesicles in intervertebral disc degeneration].
作者信息
Zhang Helong, Wei Yifan, Ma Cheng, Li Lingzhi, Tao Zhiwen, Ren Yongxin
机构信息
Department of Orthopedics, the First Affiliated Hospital of Nanjing Medical University, Nanjing Jiangsu, 210029, P. R. China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2023 Feb 15;37(2):208-214. doi: 10.7507/1002-1892.202210060.
OBJECTIVE
To review the mechanism of extracellular vesicles (EVs) in treating intervertebral disc degeneration (IVDD).
METHODS
The literature about EVs was reviewed and the biological characteristics and mechanism of EVs in the treatment of IVDD were summarized.
RESULTS
EVs are a kind of nano-sized vesicles with a double-layered lipid membrane structure secreted by many types of cells. EVs contain many bioactive molecules and participate in the exchange of information between cells, thus they play important roles in inflammation, oxidative stress, senescence, apoptosis, and autophagy. Moreover, EVs are found to slow down the process of IVDD by delaying the pathological progression of the nucleus pulposus, cartilage endplates, and annulus fibrosus.
CONCLUSION
EVs is expected to become a new strategy for the treatment of IVDD, but the specific mechanism remains to be further studied.
目的
综述细胞外囊泡（EVs）治疗椎间盘退变（IVDD）的机制。
方法
回顾有关EVs的文献，总结其生物学特性及在治疗IVDD中的机制。
结果
EVs是多种细胞分泌的具有双层脂质膜结构的纳米级囊泡。EVs含有多种生物活性分子，参与细胞间信息交换，因此在炎症、氧化应激、衰老、凋亡和自噬中发挥重要作用。此外，发现EVs可通过延缓髓核、软骨终板和纤维环的病理进展来减缓IVDD进程。
结论
EVs有望成为治疗IVDD的新策略，但具体机制仍有待进一步研究。
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