Kelleher J, Miller M G, Littlewood J M, McDonald A M, Losowsky M S
Department of Medicine, St. James's University Hospital, Leeds.
Int J Vitam Nutr Res. 1987;57(3):253-9.
Thirty patients with cystic fibrosis, 24 of whom had longstanding low serum vitamin E, were treated with 50 mg alpha-tocopherol acetate per day for periods of 18-24 months. None of the patients received haematinics during the study period. Throughout the period of study the overall clinical state of the patients did not alter significantly. The serum vitamin E level increased in all patients, but to a variable degree which was not related to the severity of steatorrhoea. A range of nutritional parameters, including anthropometry, vitamin levels, essential elements, haemoglobin and albumin, as well as dietary intake and faecal fat excretion, were assessed at the beginning and end of the study. Haemoglobin was the only parameter to change significantly from 13.14 to 13.47 g/100 ml. Twenty one of the 30 patients showed some increase in haemoglobin values and this increase could not be related to clinical state, fat absorption or dietary intake but was related to the improved vitamin E status.
30名囊性纤维化患者，其中24人长期存在血清维生素E水平低下的情况，他们每天接受50毫克醋酸生育酚治疗，为期18至24个月。在研究期间，没有患者接受补血药治疗。在整个研究期间，患者的总体临床状态没有显著改变。所有患者的血清维生素E水平均有所升高，但程度各异，且与脂肪泻的严重程度无关。在研究开始和结束时，评估了一系列营养参数，包括人体测量学指标、维生素水平、必需元素、血红蛋白和白蛋白，以及饮食摄入量和粪便脂肪排泄量。血红蛋白是唯一有显著变化的参数，从13.14克/100毫升升至13.47克/100毫升。30名患者中有21人的血红蛋白值有所升高，这种升高与临床状态、脂肪吸收或饮食摄入量无关，而是与维生素E状态的改善有关。
