Jiang M Y, Feng L Z
School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2023 Feb 6;57(2):281-285. doi: 10.3760/cma.j.cn112150-20220909-00890.
Seasonal influenza has a high disease burden, and children infected with influenza are prone to multiple complications. Influenza vaccination is effective in preventing infection and reducing risks of severe diseases and complications. Influenza vaccines are trivalent and quadrivalent, depending on the components of the vaccine. According to the hemagglutinin content, it can be divided into full dose and half dose of influenza vaccine for children. The findings from clinical trials and real-world studies suggested, the full-dose influenza vaccine as in adults has the same safety profile and higher immunogenicity in children aged 6 to 35 months. The application of full-dose influenza vaccine in children aged 6 to 35 months can greatly improve the flexibility and convenience of vaccination, and help reduce the workload in the process.
季节性流感疾病负担高，感染流感的儿童容易出现多种并发症。流感疫苗在预防感染以及降低重症和并发症风险方面有效。流感疫苗有三价和四价之分，这取决于疫苗的成分。根据血凝素含量，儿童用流感疫苗可分为全剂量和半剂量。临床试验和真实世界研究结果表明，6至35个月龄儿童接种成人剂量的全剂量流感疫苗具有与成人相同的安全性，且免疫原性更高。在6至35个月龄儿童中应用全剂量流感疫苗可大大提高接种的灵活性和便利性，并有助于减少该过程中的工作量。
