Fatouros P P, Wist A O, Kishore P R, DeWitt D S, Hall J A, Keenan R L, Stewart L M, Marmarou A, Choi S C, Kontos H A
Department of Radiology, Medical College of Virginia/Virginia Commonwealth University, Richmond 23298.
Invest Radiol. 1987 Sep;22(9):705-12. doi: 10.1097/00004424-198709000-00003.
We performed a series of five baboon experiments to compare cerebral blood flow measured with an improved stable xenon/CT method and the radiolabelled microsphere technique at a PaCO2 of 40 mm Hg. The xenon/CT method was implemented by fitting the arterial xenon uptake with a double exponential function, by measuring the oxygen and carbon dioxide concentrations continuously during each breath and by taking into account the lung-to-brain transit time of xenon. The time of xenon inhalation was extended to 30 minutes to obtain more reliable estimates of CBF in white matter regions. The results indicate an overall correlation coefficient of 0.92 between the two methods and good numeric agreement.
我们进行了一系列五项狒狒实验，以比较在动脉血二氧化碳分压为40 mmHg时，用改进的稳定氙/CT方法和放射性标记微球技术测量的脑血流量。氙/CT方法是通过用双指数函数拟合动脉血氙摄取量、在每次呼吸过程中连续测量氧气和二氧化碳浓度，并考虑氙从肺到脑的转运时间来实现的。将氙吸入时间延长至30分钟，以获得对白质区域脑血流量更可靠的估计值。结果表明，两种方法的总体相关系数为0.92，数值一致性良好。
