Department of Pediatrics, Children's Centre, Beijing Luhe Hospital Affiliated to Capital University of Medical Sciences, Beijing, China.
J Coll Physicians Surg Pak. 2023 Feb;33(2):234-236. doi: 10.29271/jcpsp.2023.02.234.
The objective of this study was to investigate the clinical effect of early administration of human immunoglobulin in children with severe hand, foot and mouth disease (HFMD) and its influence on serum c-reactive protein (CRP), creatine kinase (CK), and creatine kinase isoenzyme (CK-MB). One hundred and forty children with severe HFMD were randomly divided into Group A (n=70) and Group B (n=70) according to the random number table method. Group A was treated with routine treatment. Group B was treated with routine treatment, and an early intravenous injection of human immunoglobulin. Serum CRP, CK, and CK-MB in Group B were lower than those in Group A after treatment (all p <0.001). The total clinical effective rate of Group B was 92.9%, which was higher than that of Group A (80.0%, p=0.026). Early administration of human immunoglobulin may reduce the levels of serum markers CRP, CK, and CK-MB in children with severe HFMD. Key Words: Human immunoglobulin, Children, HFMD (Hand, foot and mouth disease).
本研究旨在探讨早期应用人免疫球蛋白对重症手足口病（HFMD）患儿的临床疗效及其对血清 C 反应蛋白（CRP）、肌酸激酶（CK）和肌酸激酶同工酶（CK-MB）的影响。将 140 例重症 HFMD 患儿按随机数字表法分为 A 组（n=70）和 B 组（n=70）。A 组给予常规治疗，B 组在常规治疗的基础上早期给予静脉注射人免疫球蛋白。治疗后 B 组血清 CRP、CK、CK-MB 均低于 A 组（均 P＜0.001）。B 组总有效率为 92.9%，高于 A 组（80.0%，P=0.026）。早期应用人免疫球蛋白可能降低重症 HFMD 患儿血清标志物 CRP、CK、CK-MB 水平。
人免疫球蛋白；儿童；HFMD（手足口病）。
