Department of Pediatrics, The First People's Hospital of Lin'an District, Hangzhou City, Zhejiang, China.
Medicine (Baltimore). 2023 Nov 24;102(47):e36162. doi: 10.1097/MD.0000000000036162.
To investigate the clinical characteristics, early blood biochemical indicators, and prognostic status of children with bronchopneumonia. We conducted a retrospective analysis of data from 500 children diagnosed with bronchopneumonia at our hospital from June 2019 to December 2022. Based on the severity of the disease, patients were assigned to the severe group (n = 180) or mild group (n = 320), and an additional 150 healthy children were chosen as the control group. Blood indicators [aspartate aminotransferase (AST), plasma carbon dioxide combining power (CO2CP), serum potassium (K+), serum sodium (Na+)], inflammatory markers [interleukin-17 (IL-17), interleukin-10 (IL-10), C-reactive protein (CRP), procalcitonin (PCT)], and cardiac enzyme profiles [lactate dehydrogenase (LDH), creatine kinase (CK), alpha-hydroxybutyrate dehydrogenase (α-HBDH), creatine kinase isoenzyme (CK-MB)] were compared among the 3 groups. The severe group showed more signs such as diarrhea, pleural effusion, and respiratory distress than the mild group. AST levels in the severe group were significantly higher than those in the mild group and control group, while CO2CP, K+, and Na+ were lower than those in the mild group and control group. AST levels in the mild group were significantly higher than those in the control group, while CO2CP and Na + were significantly higher than those in the control group (P < .05). IL-10, IL-17, PCT, and CRP levels in the severe group were higher than those in the mild group and control group, while those in the mild group were higher than those in the control group (P < .05). CK, CK-MB, LDH, and α-HBDH levels in the severe group were significantly higher than those in the mild group and control group. CK, CK-MB, LDH, and α-HBDH levels in the mild group were higher than those in the control group (P < .05). The severe group had a longer duration of fever, disappearance of symptoms, and cough relief time than the mild group (P < .05). Children with bronchopneumonia exhibit increased cardiac enzyme (CK, CK-MB, LDH, and α-HBDH) activity, and PCT and CRP expression levels increase with disease severity. Timely detection of relevant blood biochemical indicators and early implementation of prevention and treatment measures can improve the cure rate and reduce mortality in children with bronchopneumonia.
为了研究小儿支气管肺炎的临床特征、早期血液生化指标和预后状况。我们对 2019 年 6 月至 2022 年 12 月我院收治的 500 例支气管肺炎患儿的临床资料进行回顾性分析。根据疾病的严重程度，将患儿分为重症组（n=180）和轻症组（n=320），另选择 150 例健康儿童作为对照组。比较三组患儿的血液指标[天冬氨酸氨基转移酶（AST）、血浆二氧化碳结合力（CO2CP）、血清钾（K+）、血清钠（Na+）]、炎症标志物[白细胞介素-17（IL-17）、白细胞介素-10（IL-10）、C 反应蛋白（CRP）、降钙素原（PCT）]、心肌酶谱[乳酸脱氢酶（LDH）、肌酸激酶（CK）、α-羟丁酸脱氢酶（α-HBDH）、肌酸激酶同工酶（CK-MB）]。重症组腹泻、胸腔积液、呼吸困难等表现较轻症组更为明显。重症组 AST 水平明显高于轻症组和对照组，CO2CP、K+、Na+水平明显低于轻症组和对照组；轻症组 AST 水平明显高于对照组，CO2CP、Na+水平明显高于对照组（P<0.05）。重症组 IL-10、IL-17、PCT、CRP 水平明显高于轻症组和对照组，轻症组明显高于对照组（P<0.05）。重症组 CK、CK-MB、LDH、α-HBDH 水平明显高于轻症组和对照组，轻症组明显高于对照组（P<0.05）。重症组发热持续时间、症状消失时间、咳嗽缓解时间均长于轻症组（P<0.05）。支气管肺炎患儿存在心肌酶（CK、CK-MB、LDH、α-HBDH）活性升高，且 PCT、CRP 表达水平随病情严重程度增加。及时检测相关血液生化指标并早期采取防治措施，可提高小儿支气管肺炎的治愈率，降低病死率。
