Vasquez Carlos A, Evanoff Mallory, Ranzau Brodie L, Gu Sifeng, Deters Emma, Komor Alexis C
Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA.
These authors contributed equally.
bioRxiv. 2023 Feb 7:2023.02.06.527367. doi: 10.1101/2023.02.06.527367.
The flexibility and precision of CRISPR-Cas9 and related technologies have made these genome editing tools increasingly popular in agriculture, medicine, and basic science research over the past decade. Genome editing will continue to be relevant and utilized across diverse scientific fields in the future. Given this, students should be introduced to genome editing technologies and encouraged to consider their ethical implications early on in pre-college biology curricula. Furthermore, instruction on this topic presents an opportunity to create partnerships between researchers and educators at the K-12 levels that can strengthen student engagement in science, technology, engineering, and mathematics (STEM). To this end, we present a three-day student-centered learning program to introduce high school students to genome editing technologies through a hands-on base editing experiment in , accompanied by a relevant background lecture and facilitated ethics discussion. This unique partnership aims to educate students and provides a framework for research institutions to implement genome editing outreach programs at local high schools.
在过去十年中，CRISPR-Cas9及相关技术的灵活性和精确性使这些基因组编辑工具在农业、医学和基础科学研究中越来越受欢迎。未来，基因组编辑将继续在不同科学领域发挥作用并得到应用。鉴于此，应在大学预科生物学课程的早期就向学生介绍基因组编辑技术，并鼓励他们思考其伦理影响。此外，关于这一主题的教学为K-12阶段的研究人员和教育工作者建立合作关系提供了契机，这种合作可以增强学生对科学、技术、工程和数学（STEM）的参与度。为此，我们推出了一个以学生为中心的为期三天的学习项目，通过在[具体地点]进行的一个亲自动手的碱基编辑实验，向高中生介绍基因组编辑技术，并辅以相关的背景讲座和引导式伦理讨论。这种独特的合作旨在教育学生，并为研究机构在当地高中实施基因组编辑推广项目提供一个框架。
