Mi Michael Y, Gajjar Priya, Walker Maura E, Miller Patricia, Xanthakis Vanessa, Murthy Venkatesh L, Larson Martin G, Vasan Ramachandran S, Shah Ravi V, Lewis Gregory D, Nayor Matthew
medRxiv. 2023 Feb 10:2023.02.09.23285714. doi: 10.1101/2023.02.09.23285714.
To evaluate the associations of dietary indices and quantitative CRF measures in a large, community-based sample harnessing metabolomic profiling to interrogate shared biology.
Framingham Heart Study (FHS) participants underwent maximum effort cardiopulmonary exercise tests for CRF quantification (via peak VO ) and completed semi-quantitative FFQs. Dietary quality was assessed by the Alternative Healthy Eating Index (AHEI) and Mediterranean-style Diet Score (MDS), and fasting blood concentrations of 201 metabolites were quantified.
In 2380 FHS participants (54±9 years, 54% female, BMI 28±5 kg/m ), 1-SD higher AHEI and MDS were associated with 5.1% (1.2 ml/kg/min, p<0.0001) and 4.4% (1.0 ml/kg/min, p<0.0001) greater peak VO in linear models adjusted for age, sex, total energy intake, cardiovascular risk factors, and physical activity. In participants with metabolite profiling (N=1154), 24 metabolites were concordantly associated with both dietary indices and peak VO in multivariable-adjusted linear models (FDR<5%). These metabolites included C6 and C7 carnitines, C16:0 ceramide, and dimethylguanidino valeric acid, which were higher with lower CRF and poorer dietary quality and are known markers of insulin resistance and cardiovascular risk. Conversely, C38:7 phosphatidylcholine plasmalogen and C38:7 and C40:7 phosphatidylethanolamine plasmalogens were associated with higher CRF and favorable dietary quality and may link to lower cardiometabolic risk.
Higher diet quality is associated with greater CRF cross-sectionally in a middle-aged community-dwelling sample, and metabolites highlight potential shared favorable effects on health.
在一个基于社区的大样本中，利用代谢组学分析来探究共同生物学机制，评估饮食指数与定量心肺适能（CRF）指标之间的关联。
弗雷明汉心脏研究（FHS）的参与者进行了最大运动强度的心肺运动测试以量化CRF（通过峰值摄氧量），并完成了半定量的食物频率问卷。通过替代健康饮食指数（AHEI）和地中海式饮食评分（MDS）评估饮食质量，并对201种代谢物的空腹血浓度进行定量分析。
在2380名FHS参与者（年龄54±9岁，女性占54%，体重指数28±5kg/m²）中，在校正年龄、性别、总能量摄入、心血管危险因素和身体活动的线性模型中，AHEI和MDS每升高1个标准差，分别与峰值摄氧量增加5.1%（1.2ml/kg/min，p<0.0001）和4.4%（1.0ml/kg/min，p<0.0001）相关。在进行代谢物分析的参与者（N = 1154）中，在多变量校正线性模型（错误发现率<5%）中，有24种代谢物与饮食指数和峰值摄氧量均呈一致相关。这些代谢物包括C6和C7肉碱、C16:0神经酰胺以及二甲基胍基戊酸，CRF越低、饮食质量越差时它们的水平越高，它们是胰岛素抵抗和心血管风险的已知标志物。相反，C38:7磷脂酰胆碱缩醛磷脂以及C38:7和C40:7磷脂酰乙醇胺缩醛磷脂与较高的CRF和良好的饮食质量相关，可能与较低的心脏代谢风险有关。
在一个中年社区居住样本中，较高的饮食质量与横断面更高的CRF相关，并且代谢物突出了对健康潜在的共同有利影响。
