Division of Cardiovascular Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Section of Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine, Suite L-516, Boston, MA 02118, USA.
Eur J Prev Cardiol. 2023 Oct 10;30(14):1450-1461. doi: 10.1093/eurjpc/zwad113.
To evaluate the associations of dietary indices and quantitative cardiorespiratory fitness (CRF) measures in a large, community-based sample harnessing metabolomic profiling to interrogate shared biology.
Framingham Heart Study (FHS) participants underwent maximum effort cardiopulmonary exercise tests for CRF quantification (via peak VO2) and completed semi-quantitative food frequency questionnaires. Dietary quality was assessed by the Alternative Healthy Eating Index (AHEI) and Mediterranean-style Diet Score (MDS), and fasting blood concentrations of 201 metabolites were quantified. In 2380 FHS participants (54 ± 9 years, 54% female, body mass index 28 ± 5 kg/m2), 1 SD higher AHEI and MDS were associated with 5.2% (1.2 mL/kg/min, 95% CI 4.3-6.0%, P < 0.0001) and 4.5% (1.0 mL/kg/min, 95% CI 3.6-5.3%, P < 0.0001) greater peak VO2 in linear models adjusted for age, sex, total daily energy intake, cardiovascular risk factors, and physical activity. In participants with metabolite profiling (N = 1154), 24 metabolites were concordantly associated with both dietary indices and peak VO2 in multivariable-adjusted linear models (FDR < 5%). Metabolites that were associated with lower CRF and poorer dietary quality included C6 and C7 carnitines, C16:0 ceramide, and dimethylguanidino valeric acid, and metabolites that were positively associated with higher CRF and favourable dietary quality included C38:7 phosphatidylcholine plasmalogen and C38:7 and C40:7 phosphatidylethanolamine plasmalogens.
Higher diet quality is associated with greater CRF cross-sectionally in a middle-aged community-dwelling sample, and metabolites highlight potential shared favourable effects on cardiometabolic health.
利用代谢组学分析来探究共同的生物学机制，在一个大型的基于社区的样本中评估饮食指数与定量心肺功能（CRF）测量之间的关联。
弗雷明汉心脏研究（FHS）参与者进行了最大努力心肺运动测试以量化 CRF（通过峰值 VO2），并完成了半定量食物频率问卷。饮食质量通过替代健康饮食指数（AHEI）和地中海饮食评分（MDS）进行评估，定量检测了 201 种代谢物的空腹血液浓度。在 2380 名 FHS 参与者（54 ± 9 岁，54%为女性，体重指数 28 ± 5kg/m2）中，AHEI 和 MDS 每增加 1 个标准差，与峰值 VO2 分别增加 5.2%（1.2mL/kg/min，95%CI 4.3-6.0%，P<0.0001）和 4.5%（1.0mL/kg/min，95%CI 3.6-5.3%，P<0.0001）呈正相关，这些关联在调整年龄、性别、总日能量摄入、心血管危险因素和体力活动后仍然存在。在有代谢物分析的参与者中（N=1154），在多变量调整的线性模型中，有 24 种代谢物与两种饮食指数和峰值 VO2 均呈显著相关（FDR<5%）。与较低的 CRF 和较差的饮食质量相关的代谢物包括 C6 和 C7 肉碱、C16:0 神经酰胺和二甲基胍基戊酸，而与较高的 CRF 和有利的饮食质量相关的代谢物包括 C38:7 磷脂酰胆碱血小板和 C38:7 和 C40:7 磷脂酰乙醇胺血小板。
在中年社区居民样本中，较高的饮食质量与 CRF 呈横断面相关，代谢物突出了对心血管代谢健康可能存在的有利影响。
