疑似青光眼且前房角狭窄患者的α-半乳糖综合征（AGS）
Alpha-gal syndrome (AGS) in a glaucoma suspect with narrow iridocorneal angles.
作者信息
Tejan-Kamara Aminatta Z, Murhammer Joan M, Fingert John H
机构信息
Institute for Vision Research, University of Iowa, Iowa City, IA, 52242, USA.
Des Moines University, Des Moines, IA, 50312, USA.
出版信息
Am J Ophthalmol Case Rep. 2023 Jan 28;29:101811. doi: 10.1016/j.ajoc.2023.101811. eCollection 2023 Mar.
PURPOSE
Alpha-gal syndrome (AGS) is an allergy to non-primate mammalian carbohydrate (galactose-alpha-1,3-galactose) which may cause anaphylaxis. Allergic patients must avoid ophthalmic drugs containing animal-derived ingredients.
OBSERVATIONS
We report a 59-year-old non-Hispanic white woman who was referred for a glaucoma evaluation. She had been diagnosed with AGS after a tick bite in 2017. Ophthalmic exam revealed potentially occludable, narrow iridocorneal angles and laser iridotomy was recommended. Prior to performing the iridotomy, we investigated the ophthalmic medications required for the procedure to identify options that are free of animal-derived products and safe to use. Laser iridotomy was performed without complications or allergy to medications.
CONCLUSIONS
Ophthalmologists need to be aware of both the presence of AGS as well as the identity of ophthalmic medications that are safe to use in patients with this condition to avoid potentially lethal allergic responses.
目的
α-半乳糖综合征（AGS）是一种对非灵长类哺乳动物碳水化合物（半乳糖-α-1,3-半乳糖）的过敏反应，可能会引发过敏反应。过敏患者必须避免使用含有动物源性成分的眼科药物。
观察结果
我们报告了一名59岁的非西班牙裔白人女性，她因青光眼评估前来就诊。2017年她被蜱虫叮咬后被诊断出患有AGS。眼科检查发现存在潜在可闭塞的狭窄虹膜角膜角，建议进行激光虹膜切开术。在进行虹膜切开术之前，我们调查了该手术所需的眼科药物，以确定不含动物源性产品且使用安全的选项。激光虹膜切开术顺利进行，未出现并发症或药物过敏反应。
结论
眼科医生需要了解AGS的存在情况以及在此类患者中使用安全的眼科药物的种类，以避免潜在的致命过敏反应。
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