Geng Jingping, Wang Jing, Wang Hu
Department of Microbiology and Immunology, Medical School, China Three Gorges University, Yichang443002, China.
Interdisciplinary Laboratory of Molecular Biology and Biophysics, Centre of New Technologies, University of Warsaw, Banacha 2c, 02-097Warszawa, Poland.
ACS Pharmacol Transl Sci. 2023 Jan 16;6(2):229-244. doi: 10.1021/acsptsci.2c00229. eCollection 2023 Feb 10.
Organelles are specialized subunits within a cell membrane that perform specific roles or functions, and their dysfunction can lead to a variety of pathophysiologies including developmental defects, aging, and diseases (cancer, cardiovascular and neurodegenerative diseases). Recent studies have shown that cell-penetrating peptide (CPP)-based pharmacological therapies delivered to organelles or even directly resulting in organelle replacement can restore cell function and improve or prevent disease. In this review, we summarized the current developments in the precise delivery of exogenous cargoes via CPPs at the organelle level, CPP-mediated organelle delivery, and discuss their feasibility as next-generation targeting strategies for the diagnosis and treatment of diseases at the organelle level.
细胞器是细胞膜内具有特定作用或功能的特殊亚单位，其功能障碍可导致多种病理生理状况，包括发育缺陷、衰老和疾病（癌症、心血管疾病和神经退行性疾病）。最近的研究表明，基于细胞穿透肽（CPP）的药物疗法输送到细胞器甚至直接导致细胞器替代，可以恢复细胞功能并改善或预防疾病。在这篇综述中，我们总结了目前通过CPPs在细胞器水平精确递送外源货物、CPP介导的细胞器递送方面的进展，并讨论了它们作为细胞器水平疾病诊断和治疗的下一代靶向策略的可行性。
