Ma Xiaofan, Peng Jiali, Chen Yelin, Wang Zeyi, Zhou Qiang, Yan Jia, Jiang Hong
Department of Anesthesiology, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People's Hospital, Shanghai, China.
Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Dose Response. 2023 Feb 11;21(1):15593258231157563. doi: 10.1177/15593258231157563. eCollection 2023 Jan-Mar.
Esketamine, the right-handed optical isomer of racemic ketamine, has recently become widely used for anesthesia and analgesia as a replacement for racemic ketamine. However, there are limited studies comparing the anesthetic and analgesic effects of esketamine and racemic ketamine in mice. This research was conducted to analyze the dose-dependent anesthetic and analgesic efficacy of esketamine in mice and to compare its potency with that of the racemate. We tested the anesthetic effects of different doses of esketamine and compared its potency with that of the racemate using righting reflex tests. Then, the acetic acid-induced pain model and formalin-induced pain model were used to investigate the analgesic effect. Compared with racemic ketamine, an equivalent dose of esketamine at 100 mg/kg was required to induce stable anesthesia. In contrast, 5 mg/kg esketamine was sufficient to provide analgesic effects similar to those of 10 mg/kg ketamine. Together, esketamine had a similar potency to racemic ketamine for anesthesia and a stronger potency for analgesia in mice.
艾司氯胺酮是消旋氯胺酮的右旋光学异构体，最近已被广泛用作麻醉和镇痛药物，以替代消旋氯胺酮。然而，比较艾司氯胺酮和消旋氯胺酮对小鼠麻醉和镇痛作用的研究有限。本研究旨在分析艾司氯胺酮对小鼠的剂量依赖性麻醉和镇痛效果，并将其效力与消旋体进行比较。我们通过翻正反射试验测试了不同剂量艾司氯胺酮的麻醉效果，并将其效力与消旋体进行比较。然后，使用醋酸诱导的疼痛模型和福尔马林诱导的疼痛模型来研究镇痛效果。与消旋氯胺酮相比，诱导稳定麻醉需要100mg/kg的等效剂量艾司氯胺酮。相比之下，5mg/kg的艾司氯胺酮足以提供与10mg/kg氯胺酮相似的镇痛效果。总之，艾司氯胺酮在小鼠麻醉方面与消旋氯胺酮效力相似，而在镇痛方面效力更强。
