Laboratory of Molecular Basis of Behavior, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
Laboratory of Molecular Basis of Behavior, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
Eur J Pharmacol. 2019 Oct 5;860:172547. doi: 10.1016/j.ejphar.2019.172547. Epub 2019 Jul 23.
Ketamine's clinical use began in the 1970s. Physicians benefited from its safety and ability to induce short-term anesthesia and analgesia. The psychodysleptic effects caused by the drug called its further clinical use into question. Despite these unpleasant effects, ketamine is still applied in veterinary medicine, field medicine, and specialist anesthesia. Recent intensive research brought into light new possible applications of this drug. It began to be used in acute, chronic and cancer pain management. Most interesting reports come from research on the antidepressive and antisuicidal properties of ketamine giving hope for the creation of an effective treatment for major depressive disorder. Other reports highlight the possible use of ketamine in treating addiction, asthma and preventing cancer growth. Besides clinical use, the drug is also applied to in animal model of schizophrenia. It seems that nowadays, with numerous possible applications, the use of ketamine has returned; to its former glory. Nevertheless, the drug must be used with caution because still the mechanisms by which it executes its functions and long-term effects of its use are not fully known. This review aims to discuss the well-known and new promising applications of ketamine.
氯胺酮的临床应用始于 20 世纪 70 年代。其安全性和诱导短期麻醉和镇痛的能力使医生受益。该药物引起的精神错乱作用使其进一步的临床应用受到质疑。尽管存在这些不良影响，氯胺酮仍在兽医、野战医学和专科麻醉中应用。最近的深入研究揭示了这种药物的新的可能应用。它开始用于急性、慢性和癌症疼痛管理。最有趣的报告来自于氯胺酮抗抑郁和抗自杀特性的研究，这为开发治疗重度抑郁症的有效药物带来了希望。其他报告强调了氯胺酮在治疗成瘾、哮喘和预防癌症生长方面的可能用途。除了临床应用，该药物还应用于精神分裂症动物模型。如今，随着氯胺酮可能应用的增加，其用途似乎又回到了昔日的辉煌。然而，由于其作用机制和长期使用效果尚未完全了解，该药物的使用必须谨慎。本文旨在讨论氯胺酮的已知和新的有前途的应用。
