病例报告：MMR 缺陷型子宫内膜癌分泌甲状旁腺激素导致危及生命的高钙血症。
Case Report: Life-threatening hypercalcemia associated with MMR-deficient endometrial carcinoma secreting parathyroid hormone.
机构信息
Department of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
出版信息
Front Endocrinol (Lausanne). 2023 Jan 31;14:1125822. doi: 10.3389/fendo.2023.1125822. eCollection 2023.
Ectopic secretion of parathyroid hormone (PTH) is a rare cause of hypercalcemia in malignancy patients. A 56-year-old woman with life-threatening hypercalcemia was caused by poorly-differentiated endometrial carcinoma secreting PTH with concomitant nodular goiter mimic parathyroid tumors. The elevated level of PTH and calcium decreased immediately after cytoreductive surgery (CRS). The pathology confirmed mismatch repair (MMR)-deficient endometrial carcinoma with PTH expression. The patient received four-course chemotherapy and one-course immunotherapy after CRS. The disease progression led to multiple organ failure and death about five months after CRS. To our knowledge, this is the first case of hypercalcemia caused by MMR-deficient endometrial carcinoma with ectopic PTH secreting and the first report of malignancy associated hypercalcemia complicated with nodular goiter.
甲状旁腺激素（PTH）异位分泌是恶性肿瘤患者高钙血症的罕见原因。一位 56 岁女性因 PTH 分泌的低分化子宫内膜癌导致危及生命的高钙血症，同时伴有甲状旁腺肿瘤样结节性甲状腺肿。PTH 和钙水平升高在细胞减灭性手术（CRS）后立即降低。病理证实 PTH 表达的错配修复（MMR）缺陷型子宫内膜癌。CRS 后，该患者接受了四疗程化疗和一疗程免疫治疗。疾病进展导致多器官衰竭，并在 CRS 后约五个月死亡。据我们所知，这是首例由 MMR 缺陷型子宫内膜癌伴异位 PTH 分泌引起的高钙血症，也是首例报道的恶性肿瘤相关高钙血症合并结节性甲状腺肿的病例。
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