Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, Zhejiang, China.
Oxid Med Cell Longev. 2023 Feb 7;2023:3842493. doi: 10.1155/2023/3842493. eCollection 2023.
Subarachnoid hemorrhage (SAH) refers to vascular brain injury mainly from a ruptured aneurysm, which has a high lifetime risk and imposes a substantial burden on patients, families, and society. Previous studies on SAH mainly focused on neurons in gray matter (GM). However, according to literature reports in recent years, in-depth research on the mechanism of white matter (WM) is of great significance to injury and recovery after SAH. In terms of functional recovery after SAH, all kinds of cells in the central nervous system (CNS) should be protected. In other words, it is necessary to protect not only GM but also WM, not only neurons but also glial cells and axons, and not only for the lesion itself but also for the prevention and treatment of remote damage. Clarifying the mechanism of white matter injury (WMI) and repair after SAH is of great importance. Therefore, this present review systematically summarizes the current research on WMI after SAH, which might provide therapeutic targets for treatment after SAH.
蛛网膜下腔出血 (SAH) 是指主要由破裂的动脉瘤引起的血管性脑损伤，具有很高的终生风险，给患者、家庭和社会带来了沉重的负担。先前关于 SAH 的研究主要集中在灰质 (GM) 的神经元上。然而，根据近年来的文献报道，深入研究白质 (WM) 的机制对于 SAH 后的损伤和恢复具有重要意义。就 SAH 后的功能恢复而言，中枢神经系统 (CNS) 中的各种细胞都需要得到保护。换句话说，不仅要保护 GM，还要保护 WM，不仅要保护神经元，还要保护神经胶质细胞和轴突，不仅要针对病变本身，还要针对远程损伤的预防和治疗。阐明 SAH 后 WM 损伤 (WMI) 的机制具有重要意义。因此，本综述系统总结了目前关于 SAH 后 WMI 的研究，这可能为 SAH 后的治疗提供治疗靶点。
