Ozmeric Nurdan, Elgun Serenay, Kalfaoglu Duygu, Pervane Beste, Sungur Çağlar, Ergüder İmge, Yavuz Yasemin
Department of Periodontology, Cyprus International University Faculty of Dentistry, Nicosia, Cyprus.
Department of Periodontology, Gazi University Faculty of Dentistry, Ankara, Turkey.
Oral Dis. 2024 Apr;30(3):1622-1631. doi: 10.1111/odi.14543. Epub 2023 Mar 13.
The possible association between hypertension and periodontitis and the effect of hypertension on periodontal treatment were investigated by evaluating salivary and gingival crevicular fluid (GCF) interleukin (IL)-6 and C reactive protein (CRP) levels.
Forty-two healthy individuals without any previously diagnosed systemic disease [10 periodontally healthy (control) and 10 periodontitis (CP)] and subjects with hypertension [13 periodontally healthy (HP) and 9 with periodontitis (CP + HP)] participated in the study. GCF and saliva samples were obtained at baseline and 4 weeks after Phase I periodontal treatment. Biochemical parameters were analyzed using ELISA.
Before the periodontal treatment, significantly higher GCF IL-6 and CRP levels were detected in CP + HP and CP groups compared to HP and control groups (p < 0.01). Salivary CRP level in CP + HP group was found to be higher than the control group (p < 0.05). Statistically significant gingival and plaque index measurements (p < 0.01) might suggest a possible effect of hypertension on periodontal status. Periodontal treatment significantly improved the clinical indices; however, biochemical parameters did not change after the treatment.
The association of hypertension with periodontitis through local salivary and GCF inflammatory mediators might be possible in disease process.
通过评估唾液和龈沟液（GCF）中白细胞介素（IL）-6和C反应蛋白（CRP）水平，研究高血压与牙周炎之间可能存在的关联以及高血压对牙周治疗的影响。
42名未曾被诊断出患有任何全身性疾病的健康个体[10名牙周健康者（对照组）和10名牙周炎患者（慢性牙周炎组）]以及高血压患者[13名牙周健康者（高血压牙周健康组）和9名牙周炎患者（慢性牙周炎合并高血压组）]参与了本研究。在牙周治疗第一阶段的基线期和4周后采集龈沟液和唾液样本。使用酶联免疫吸附测定法分析生化参数。
在牙周治疗前，慢性牙周炎合并高血压组和慢性牙周炎组龈沟液中的IL-6和CRP水平显著高于高血压牙周健康组和对照组（p<0.01）。慢性牙周炎合并高血压组的唾液CRP水平高于对照组（p<0.05）。具有统计学意义的牙龈和菌斑指数测量结果（p<0.01）可能提示高血压对牙周状况有潜在影响。牙周治疗显著改善了临床指标；然而，治疗后生化参数并未改变。
在疾病过程中，高血压可能通过局部唾液和龈沟液中的炎症介质与牙周炎相关联。
