Fu Di, Shu Xingyue, Zhou Ge, Ji Mengzhen, Liao Ga, Zou Ling
State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases Sichuan University Chengdu Sichuan China.
Department of Information Management, Department of Stomatology Informatics, West China Hospital of Stomatology Sichuan University Chengdu Sichuan China.
MedComm (2020). 2025 Jan 14;6(1):e70052. doi: 10.1002/mco2.70052. eCollection 2025 Jan.
Chronic diseases have emerged as a paramount global health burden, accounting for 74% of global mortality and causing substantial economic losses. The oral cavity serves as a critical indicator of overall health and is inextricably linked to chronic disorders. Neglecting oral health can exacerbate localized pathologies and accelerate the progression of chronic conditions, whereas effective management has the potential to reduce their incidence and mortality. Nevertheless, limited resources and lack of awareness often impede timely dental intervention, delaying optimal therapeutic measures. This review provides a comprehensive analysis of the impact of prevalent chronic diseases-such as diabetes mellitus, rheumatoid arthritis, cardiovascular disorders, and chronic respiratory diseases-on oral health, along with an exploration of how changes in oral health affect these chronic conditions through both deterioration and intervention mechanisms. Additionally, novel insights into the underlying pathophysiological mechanisms governing these relationships are presented. By synthesizing these advancements, this review aims to illuminate the complex interrelationship between oral health and chronic diseases while emphasizing the urgent need for greater collaboration between dental practitioners and general healthcare providers to improve overall health outcomes.
慢性病已成为全球首要的健康负担，占全球死亡率的74%，并造成巨大的经济损失。口腔是整体健康的关键指标，与慢性疾病有着千丝万缕的联系。忽视口腔健康会加剧局部病变，并加速慢性病的发展，而有效的管理则有可能降低其发病率和死亡率。然而，资源有限和意识缺乏往往阻碍及时的牙科干预，延误最佳治疗措施。本综述全面分析了糖尿病、类风湿性关节炎、心血管疾病和慢性呼吸道疾病等常见慢性病对口腔健康的影响，并探讨了口腔健康的变化如何通过恶化和干预机制影响这些慢性病。此外，还介绍了对这些关系背后病理生理机制的新见解。通过综合这些进展，本综述旨在阐明口腔健康与慢性病之间的复杂相互关系，同时强调牙科医生和普通医疗服务提供者之间迫切需要加强合作，以改善整体健康结果。
