School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, 211816, P. R. China.
School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, P. R. China.
Small. 2023 Aug;19(31):e2207385. doi: 10.1002/smll.202207385. Epub 2023 Feb 17.
The emergence and global spread of bacterial resistance to conventionally used antibiotics have highlighted the urgent need for new antimicrobial agents that might replace antibiotics. Currently, nanomaterials hold considerable promise as antimicrobial agents in anti-inflammatory therapy. Due to their distinctive functional physicochemical characteristics and exceptional biocompatibility, carbon dots (CDs)-based composites have attracted a lot of attention in the context of these antimicrobial nanomaterials. Here, a thorough assessment of current developments in the field of antimicrobial CDs-based composites is provided, starting with a brief explanation of the general synthesis procedures, categorization, and physicochemical characteristics of CDs-based composites. The many processes driving the antibacterial action of these composites are then thoroughly described, including physical destruction, oxidative stress, and the incorporation of antimicrobial agents. Finally, the obstacles that CDs-based composites now suffer in combating infectious diseases are outlined and investigated, along with the potential applications of antimicrobial CDs-based composites.
细菌对传统抗生素的耐药性的出现和全球传播,突出表明迫切需要新的抗菌剂来替代抗生素。目前,纳米材料作为抗炎治疗中的抗菌剂具有很大的潜力。由于其独特的功能物理化学特性和卓越的生物相容性,基于碳点(CDs)的复合材料在这些抗菌纳米材料的背景下引起了广泛关注。在这里,我们对基于 CD 的抗菌复合材料领域的当前发展进行了全面评估,首先简要解释了 CD 基复合材料的一般合成程序、分类和物理化学特性。然后,详细描述了这些复合材料发挥抗菌作用的多种过程,包括物理破坏、氧化应激和抗菌剂的掺入。最后,概述并研究了基于 CD 的复合材料在治疗传染病方面目前面临的障碍,以及基于 CD 的抗菌复合材料的潜在应用。