Okuda Shuto, Narita Yutaka, Hayashi Rikuo, Sai Masahiro
Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Chem Commun (Camb). 2023 Mar 7;59(20):2939-2942. doi: 10.1039/d2cc07097a.
This paper describes the regio- and diastereoselective synthesis of unsymmetrical 1,4-diketone-derived ()-monosilyl enol ethers from 1-arylallyloxysilanes and Weinreb amides using (trimethylsilyl)methylpotassium as a base. The metalation of 1-arylallyloxysilanes to generate siloxyallylpotassiums is the key step in this transformation. The products can be transformed into diverse α-monofunctionalized unsymmetrical 1,4-diketones.
本文描述了以（三甲基甲硅烷基）甲基钾为碱，从1-芳基烯丙氧基硅烷和Weinreb酰胺区域和非对映选择性合成不对称1,4-二酮衍生的（）-单硅基烯醇醚。1-芳基烯丙氧基硅烷金属化生成硅氧基烯丙基钾是该转化的关键步骤。产物可转化为多种α-单官能化不对称1,4-二酮。
