Department of Pediatrics, Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Fetal Pediatr Pathol. 2023 Aug;42(4):569-580. doi: 10.1080/15513815.2023.2177129. Epub 2023 Feb 17.
Previous research demonstrated the association between cyclooxygenase-2 (COX-2) gene polymorphisms and susceptibility to Kawasaki disease (KD). This study aims to detect the plasma concentration of COX-2 in different phases of KD patients and evaluate the relationship between COX-2 level and coronary artery lesion formation, therapeutic response to intravenous immunoglobulin. Plasma COX-2 levels were measured by enzyme-linked immunosorbent assay in KD patients during the acute (a-KD, = 52), subacute (s-KD, = 46), and convalescent (c-KD, = 43) phase. The concentration of COX-2 in the a-KD group was significantly higher than that in the s-KD, c-KD, healthy control or febrile control group, respectively. There was no difference in the levels of COX-2 between the KD with or without coronary artery lesion subgroups, intravenous immunoglobulin resistant, and sensitive subgroups in the a-KD group, respectively. The plasma concentration of COX-2 might be a novel potential biomarker of acute KD.
先前的研究表明环氧化酶-2（COX-2）基因多态性与川崎病（KD）易感性之间存在关联。本研究旨在检测不同时期 KD 患者的 COX-2 血浆浓度，并评估 COX-2 水平与冠状动脉损伤形成、静脉注射免疫球蛋白治疗反应之间的关系。通过酶联免疫吸附试验测量 KD 患者在急性期（a-KD，n=52）、亚急性期（s-KD，n=46）和恢复期（c-KD，n=43）的 COX-2 血浆浓度。a-KD 组 COX-2 的浓度明显高于 s-KD、c-KD、健康对照组或发热对照组。a-KD 组中，有或无冠状动脉损伤亚组、静脉注射免疫球蛋白耐药和敏感亚组之间 COX-2 水平无差异。COX-2 的血浆浓度可能是急性 KD 的一个新的潜在生物标志物。
