Key Laboratory for Photonic and Electronic Bandgap Materials, Ministry of Education, School of Chemistry & Chemical Engineering, Harbin Normal University, Harbin, 150025, China.
Protein Pept Lett. 2023;30(3):201-213. doi: 10.2174/0929866530666230217160717.
Chemotherapy is one of the most important treatment modalities for liver cancer, especially for those who are judged as being unsuitable for surgical resection, local ablative therapy, or transarterial chemoembolization. However, the efficacy of chemotherapy is still unsatisfactory due to the long duration, side effects and the tendency to develop drug resistance. The development of novel anti-liver cancer drugs remains imperative. Cyclopeptides have been recognized as new chemical modalities in drug design due to their unique constrained structures, extensive biological activities, higher metabolic stability, cell permeability and bioavailability than linear peptides. A lot of cyclic peptides have been found with potential anti-proliferative activity against malignant cells, and many of them showed excellent anti-liver cancer activity. In this review, we will discuss in detail the structures and the anti-liver cancer activity of small and medium-sized cyclopeptides, aiming to offer some elicitation to chemotherapeutic drug design based on cyclopeptides.
化疗是肝癌最重要的治疗方法之一，特别是对于那些被认为不适合手术切除、局部消融治疗或经动脉化疗栓塞的患者。然而，由于化疗持续时间长、副作用大且易产生耐药性，其疗效仍不尽人意。因此，开发新型肝癌治疗药物迫在眉睫。环肽由于其独特的约束结构、广泛的生物活性、比线性肽更高的代谢稳定性、细胞通透性和生物利用度，已被认为是药物设计中的新型化学模式。已经发现许多具有潜在抗增殖活性的环肽对抗恶性细胞，其中许多环肽表现出优异的抗肝癌活性。在这篇综述中，我们将详细讨论小分子和中分子环肽的结构和抗肝癌活性，旨在为基于环肽的化疗药物设计提供一些启示。
