Moriello K A, Bowen D, Meyer D J
Department of Medical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610.
J Am Vet Med Assoc. 1987 Sep 15;191(6):695-6.
Acute pancreatitis was diagnosed in 2 dogs given azathioprine and prednisone. Prednisone and azathioprine had been given as immunosuppressive therapy for pemphigus foliaceus in dog 1 and for polymyositis in dog 2. Azathioprine was discontinued in both dogs. In dog 1, prednisone was reinstituted on day 6 of hospitalization. Prednisone was continued throughout the period of hospitalization in dog 2. Both dogs recovered without complication. Glucocorticoid therapy has been associated with the development of pancreatitis. In human beings, a common side effect of azathioprine is the development of drug-induced pancreatitis. Definitive identification of azathioprine as the cause of pancreatitis in these dogs was not possible; the owners refused to permit retreatment with the drug. Therefore, the synergistic action between these 2 drugs could not be ruled out as the cause of pancreatitis.
2只接受硫唑嘌呤和泼尼松治疗的犬被诊断为急性胰腺炎。泼尼松和硫唑嘌呤作为免疫抑制疗法分别用于犬1的落叶型天疱疮和犬2的多发性肌炎。两只犬均停用硫唑嘌呤。犬1在住院第6天重新开始使用泼尼松。犬2在整个住院期间持续使用泼尼松。两只犬均康复且无并发症。糖皮质激素治疗与胰腺炎的发生有关。在人类中，硫唑嘌呤的常见副作用是药物性胰腺炎的发生。无法明确确定硫唑嘌呤是这些犬胰腺炎的病因；犬主拒绝允许再次使用该药物进行治疗。因此，不能排除这两种药物之间的协同作用是胰腺炎的病因。
