Highcroft Veterinary Referrals, Bristol, UK.
School of Veterinary Medicine and Sciences, University of Nottingham Sutton Bonington Campus, Leicestershire, UK.
J Vet Intern Med. 2023 Mar;37(2):670-675. doi: 10.1111/jvim.16655. Epub 2023 Feb 17.
A 3-month-old female entire Beagle presented with a progressive history of caudotentorial encephalopathy. Reactive encephalopathies were ruled out and tests for the most common infectious diseases agents were negative. Magnetic resonance imaging of the brain using a 1.5 Tesla scanner showed diffuse, bilateral, T2-weighted and T2-weighted-FLAIR hyperintense, T1-weighted hypointense, noncontrast-enhancing lesions involving the white matter of the cerebellum, brainstem, spinal cord, and forebrain to a lesser extent. There was cerebellar enlargement. Abnormalities were not detected on cerebrospinal fluid examination. Given the progressive nature of the disease and suspected poor prognosis the dog was euthanized. Histopathological analysis of the brain was consistent with fibrinoid leukodystrophy, also known as Alexander disease. Based on the classification used in humans, this is a description of MRI of a case of type II Alexander disease in veterinary medicine, with characteristics different to other described leukoencephalopathies in dogs.
一只 3 月龄雌性全贝克犬出现进行性颅尾脑病病史。排除反应性脑病，并对最常见的传染病病原体进行了检测，结果均为阴性。使用 1.5T 扫描仪对大脑进行磁共振成像显示，小脑、脑干、脊髓和前脑的白质弥漫性、双侧、T2 加权和 T2 加权-FLAIR 高信号，T1 加权低信号，非增强病变，小脑肿大。脑脊液检查未发现异常。鉴于疾病的进行性和可疑的预后不良，对该犬实施了安乐死。脑的组织病理学分析与纤维蛋白样脑白质营养不良一致，也称为亚历山大病。根据在人类中使用的分类，这是兽医中 II 型亚历山大病的 MRI 描述，与其他描述的犬脑白质疾病不同。
