Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Department of Chemistry, Tarbiat Modares University, P.O. Box 14115-175, Tehran, Iran.
Mol Divers. 2024 Feb;28(1):85-95. doi: 10.1007/s11030-023-10610-0. Epub 2023 Feb 17.
A catalyst-free synthesis of stable bis-spiropyrrolidines from isatin, secondary amines, and alkylidene Meldrum's acids in MeCN in 75-95% yield is described. The antioxidant and antimicrobial properties of the synthesized compounds are investigated. For this purpose, the radical scavenging activities of four derivatives were studied by radical trapping of diphenylpicrylhydrazine and ferric reduction power experiments. Disk diffusion test on Gram-positive and Gram-negative bacteria was employed to investigate antibacterial activities of five derivatives.
本文描述了一种在 MeCN 中，通过靛红、仲胺和亚甲基 Meldrum's 酸无催化剂合成稳定双螺吡咯烷的方法，产率为 75-95%。研究了合成化合物的抗氧化和抗菌性能。为此，通过二苯基苦基肼的自由基捕获和铁还原能力实验研究了四个衍生物的自由基清除活性。采用革兰氏阳性菌和革兰氏阴性菌的圆盘扩散试验研究了五个衍生物的抗菌活性。
