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Synthesis and biological properties of 7 beta-[(Z)-2-(2-amino-4-thiazolyl)-4-carboxy-2-butenoylamino]-3-cephem- 4-carboxylic acid (7432-S), a new oral cephem antibiotic.

作者信息

Hamashima Y, Kubota T, Minami K, Ishikura K, Konoike T, Yoshioka M, Yoshida T, Nakashimizu H, Motokawa K

机构信息

Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.

出版信息

J Antibiot (Tokyo). 1987 Oct;40(10):1468-70. doi: 10.7164/antibiotics.40.1468.

DOI:10.7164/antibiotics.40.1468
PMID:3680016
Abstract
摘要

相似文献

1
Synthesis and biological properties of 7 beta-[(Z)-2-(2-amino-4-thiazolyl)-4-carboxy-2-butenoylamino]-3-cephem- 4-carboxylic acid (7432-S), a new oral cephem antibiotic.
J Antibiot (Tokyo). 1987 Oct;40(10):1468-70. doi: 10.7164/antibiotics.40.1468.
2
Synthetic studies on beta-lactam antibiotics. Part 101. Synthesis of 7beta-[2-carboxy-2-(4-hydroxyphenyl)acetamido]-7alpha-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]-methyl]-1-oxa-1-dethia-3-cephem-4-carboxylic acid disodium salt (6059-S) and its related 1-oxacephems.
J Med Chem. 1979 Jul;22(7):757-9. doi: 10.1021/jm00193a001.
3
Studies on beta-lactam antibiotics. X. Synthesis and structure-activity relationships of 7 beta-[(Z)-2-(2-amino-4-thiazolyl)-2-(carboxymethoxyimino)acetamido] cephalosporin derivatives.β-内酰胺抗生素的研究。十、7β-[(Z)-2-(2-氨基-4-噻唑基)-2-(羧基甲氧基亚氨基)乙酰胺基]头孢菌素衍生物的合成及构效关系
J Antibiot (Tokyo). 1986 Jan;39(1):101-10. doi: 10.7164/antibiotics.39.101.
4
Studies on beta-lactam antibiotics VIII. Structure-activity relationships of 7 beta-[(Z)-2-carboxymethoxyimino-2-arylacetamido]-3-cephem- 4-carboxylic acids.
J Antibiot (Tokyo). 1985 Aug;38(8):1068-76. doi: 10.7164/antibiotics.38.1068.
5
Studies on beta-lactam antibiotics. I. Synthesis and in vitro anti-pseudomonal activity of 3-isothiazole-cephalosporin derivatives.β-内酰胺类抗生素的研究。I. 3-异噻唑头孢菌素衍生物的合成及其体外抗假单胞菌活性
J Antibiot (Tokyo). 1987 Feb;40(2):173-81. doi: 10.7164/antibiotics.40.173.
6
Synthesis and antibacterial activity of novel aminothiazolyl beta-lactam derivatives.新型氨基噻唑基β-内酰胺衍生物的合成与抗菌活性
J Antibiot (Tokyo). 1986 Mar;39(3):372-9. doi: 10.7164/antibiotics.39.372.
7
Synthetic cephalosporins. II. The synthesis and oral activity of 7-[R-2-amino-2-(3-chloro-4-hydroxyphenyl)acetamido]-3-methylthio-3- cephem-4-carboxylic acid and related compounds.合成头孢菌素。II. 7-[R-2-氨基-2-(3-氯-4-羟基苯基)乙酰胺基]-3-甲硫基-3-头孢烯-4-羧酸及相关化合物的合成与口服活性
J Antibiot (Tokyo). 1987 Sep;40(9):1325-30. doi: 10.7164/antibiotics.40.1325.
8
Ceftibuten
9
Synthesis of 7 beta-[(Z)-2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido]-3-cephem-4- carboxylic acid (ceftizoxime), a new semisynthetic cephalosporin antibiotic. I. An improved method for the preparation of 7-amino-3-methylene- and 7-amino-3-hydroxycepham-4-carboxylic acid.新型半合成头孢菌素抗生素7β-[(Z)-2-(2-氨基-4-噻唑基)-2-甲氧基亚氨基乙酰胺基]-3-头孢烯-4-羧酸（头孢唑肟）的合成。I. 7-氨基-3-亚甲基-和7-氨基-3-羟基头孢烷-4-羧酸的改进制备方法。
Chem Pharm Bull (Tokyo). 1988 Feb;36(2):582-91. doi: 10.1248/cpb.36.582.
10
Orally absorbable D-forphenicinol-cephalosporins.口服可吸收的 D-去甲环丙沙星头孢菌素。
J Antibiot (Tokyo). 1989 Jun;42(6):993-9. doi: 10.7164/antibiotics.42.993.

引用本文的文献

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Characterization of beta-lactamase gene blaPER-2, which encodes an extended-spectrum class A beta-lactamase.编码超广谱A类β-内酰胺酶的β-内酰胺酶基因blaPER-2的特征分析。
Antimicrob Agents Chemother. 1996 Mar;40(3):616-20. doi: 10.1128/AAC.40.3.616.
2
Comparative in vitro activity of ceftibuten (Sch 39720) against bacterial enteropathogens.头孢布烯（Sch 39720）对细菌性肠道病原体的体外活性比较
Antimicrob Agents Chemother. 1989 May;33(5):781-4. doi: 10.1128/AAC.33.5.781.
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In vitro antibacterial properties of cefetamet and in vivo activity of its orally absorbable ester derivative, cefetamet pivoxil.
头孢他美酯的体外抗菌特性及其口服吸收酯衍生物头孢他美酯匹伏酯的体内活性。
Eur J Clin Microbiol Infect Dis. 1989 Jun;8(6):536-43. doi: 10.1007/BF01967476.
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[Antibacterial activity and beta-lactamase stability of eleven oral cephalosporins].十一种口服头孢菌素的抗菌活性及β-内酰胺酶稳定性
Infection. 1990;18 Suppl 3:S155-67. doi: 10.1007/BF01644637.