Macrolide biosynthesis: stereochemistry of the hydroxylation of brefeldin C.
作者信息
Gonzalez de la Parra M, Hutchinson C R
机构信息
School of Pharmacy, University of Wisconsin, Madison 53706.
出版信息
J Antibiot (Tokyo). 1987 Aug;40(8):1170-4. doi: 10.7164/antibiotics.40.1170.
PMID:3680028
Abstract
Brefeldin C (2) is the penultimate intermediate in the biosynthetic pathway to brefeldin A (1). Using stereospecifically 2H-labeled forms of 2, the hydroxylation of 2 to 1 is shown to involve stereospecific removal of the 7 pro-S hydrogen from 2.
摘要
Zotero 插件