Department of Chemical Sciences, Indian Institute of Science Education and Research-Kolkata, Mohanpur 741246, India.
Org Lett. 2023 Mar 3;25(8):1305-1309. doi: 10.1021/acs.orglett.3c00223. Epub 2023 Feb 17.
The present study demonstrates the first transition-metal-free catalytic C-alkylation via a borrowing hydrogen pathway for the α-alkylation of ketone, synthesis of substituted quinoline, and 9-monoalkylation of fluorene. With applications on diversification of biologically active molecules and gram-scale synthesis, a preliminary investigation of the reaction mechanism has been carried out, suggesting a radical-mediated borrowing hydrogen pathway.
本研究展示了首例通过借氢途径实现酮的α-烷基化、取代喹啉合成以及芴的 9-单烷基化的首例过渡金属自由催化 C-烷基化反应。通过在生物活性分子的多样化和克级合成方面的应用，我们对反应机制进行了初步研究，表明这是一种自由基介导的借氢途径。
