Borg E, Viberg A
Dept. of Audiology, Karolinska hospital, Stockholm, Sweden.
Hear Res. 1987;30(2-3):111-8. doi: 10.1016/0378-5955(87)90128-6.
In the spontaneously hypertensive (SH) rat, a hereditary form of hypertension and widespread vascular abnormalities develop. In the present study the inner ear degeneration pattern in SH and normotensive (N) rats not exposed to noise was investigated and correlated with frequency-specific auditory brainstem response (ABR) thresholds. Rats of both strains were found to have a spontaneous loss of apical hair cells, but this was slightly more pronounced in SH. In SH rats, but not in those of the N strain, there was an age-related progressive loss of outer hair cells in the region 3-5 mm from the stapes, and a slight additional loss at the most basal end. According to available frequency maps, the hair cell loss should correspond to hearing loss between 6 and 24 kHz. In the SH rats hearing loss was not observed in the whole of this range, only at 16 and 20 kHz. It cannot be determined to what extent the localized spontaneous loss of hair cells is caused by vascular factors and what other mechanisms are involved, but vascular factors probably only play a minor role.
在自发性高血压（SH）大鼠中，会出现一种遗传性高血压形式以及广泛的血管异常。在本研究中，对未暴露于噪声的SH大鼠和正常血压（N）大鼠的内耳退化模式进行了研究，并将其与频率特异性听觉脑干反应（ABR）阈值相关联。发现两种品系的大鼠均存在顶端毛细胞的自发性损失，但在SH大鼠中这种损失更为明显。在SH大鼠中，而不是N品系大鼠中，在距镫骨3 - 5毫米区域存在与年龄相关的外毛细胞渐进性损失，并且在最基部末端还有轻微的额外损失。根据现有的频率图，毛细胞损失应对应于6至24千赫兹之间的听力损失。在SH大鼠中，并非在整个该范围内都观察到听力损失，仅在16和20千赫兹时出现。尚无法确定局部毛细胞的自发性损失在多大程度上是由血管因素引起的，以及涉及哪些其他机制，但血管因素可能仅起次要作用。
