Department of Pharmacology, Ehime University Graduate School of Medicine, Matsuyama, Japan.
Department of Ophthalmology, Ehime University Graduate School of Medicine, Matsuyama, Japan.
Hypertens Res. 2024 May;47(5):1246-1259. doi: 10.1038/s41440-024-01642-6. Epub 2024 Mar 15.
Hypertension, a disease whose prevalence increases with age, induces pathological conditions of ischemic vascular disorders such as cerebral infarction and myocardial infarction due to accelerated arteriosclerosis and circulatory insufficiency of small arteries and sometimes causes hemorrhagic conditions such as cerebral hemorrhage and ruptured aortic aneurysm. On the other hand, as it is said that aging starts with the blood vessels, impaired blood flow associated with vascular aging is the basis for the development of many pathological conditions, and ischemic changes in target organs associated with vascular disorders result in tissue dysfunction and degeneration, inducing organ hypofunction and dysfunction. Therefore, we hypothesized that hypertension is associated with all age-related vascular diseases, and attempted to review the relationship between hypertension and diseases for which a relationship has not been previously well reported. Following our review, we hope that a collaborative effort to unravel age-related diseases from the perspective of hypertension will be undertaken together with experts in various specialties regarding the relationship of hypertension to all pathological conditions.
高血压是一种随着年龄增长而患病率增加的疾病,由于动脉粥样硬化加速和小动脉循环不足,会导致脑梗死和心肌梗死等缺血性血管疾病,有时还会导致脑出血和主动脉瘤破裂等出血性疾病。另一方面,由于人们常说血管老化始于血液,因此与血管老化相关的血流受损是许多病理状况发展的基础,而与血管疾病相关的靶器官缺血性改变会导致组织功能障碍和退化,从而导致器官功能减退和功能障碍。因此,我们假设高血压与所有与年龄相关的血管疾病都有关联,并试图回顾高血压与以前未被充分报道的疾病之间的关系。在我们的综述之后,我们希望与各个专业领域的专家一起,从高血压的角度共同努力,阐明与高血压相关的所有病理状况。