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足月经产妇应用双球囊导管与地诺前列酮行引产的效果及安全性。

Efficacy and safety of double balloon catheter and dinoprostone for labor induction in multipara at term.

机构信息

Department of Obstetrics, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, No. 745, Wuluo Road, Hongshan District, Wuhan, 430070, China.

出版信息

Arch Gynecol Obstet. 2024 Feb;309(2):533-540. doi: 10.1007/s00404-022-06891-9. Epub 2023 Feb 20.

DOI:10.1007/s00404-022-06891-9
PMID:36801968
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10808154/
Abstract

PURPOSE

The aim of this study was to comparatively assess the efficacy and safety of double balloon catheter (DBC) and dinoprostone as labor-inducing agents just for multipara at term.

METHODS

A retrospective cohort study was conducted among multipara at term with a Bishop score < 6 who needed planned labor induction from January 1, 2020, to December 30, 2020 in Maternal and Child Health Hospital of Hubei province, Tongji Medical College, Huazhong University of Science and Technology. They were divided into DBC group and dinoprostone group, respectively. Baseline maternal data, maternal and neonatal outcomes were recorded for statistical analysis. Total vaginal delivery rate, rate of vaginal delivery within 24 h, rate of uterine hyperstimulation combined with abnormal fetal heart rate(FHR) were regarded as the primary outcome variables. The difference between groups was considered statistically significant when p value < 0.05.

RESULTS

A total of 202 multiparas was included for analysis (95 women in DBC group vs 107 women in dinoprostone group). There were no significant differences in total vaginal delivery rate and rate of vaginal delivery within 24 h between groups. Uterine hyperstimulation combined with abnormal FHR occurred exclusively in dinoprostone group.

CONCLUSION

DBC and dinoprostone seem to be equally effective, while, DBC seems to be safer than dinoprostone.

摘要

目的

本研究旨在比较双球囊导管（DBC）和地诺前列酮作为足月多产妇引产药物的疗效和安全性。

方法

回顾性队列研究纳入 2020 年 1 月 1 日至 2020 年 12 月 30 日期间，在华中科技大学同济医学院附属湖北省妇幼保健院，因 Bishop 评分<6 需要计划分娩的足月多产妇。将其分为 DBC 组和地诺前列酮组，分别记录产妇基线数据、母婴结局进行统计学分析。总阴道分娩率、24 小时内阴道分娩率、子宫过度刺激合并异常胎心（FHR）率作为主要结局变量。当 p 值<0.05 时，认为组间差异具有统计学意义。

结果

共纳入 202 例多产妇进行分析（DBC 组 95 例，地诺前列酮组 107 例）。两组总阴道分娩率和 24 小时内阴道分娩率无统计学差异。仅在地诺前列酮组出现子宫过度刺激合并异常 FHR。

结论

DBC 和地诺前列酮似乎同样有效，而 DBC 似乎比地诺前列酮更安全。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3379/10808154/41ff16ca23df/404_2022_6891_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3379/10808154/41ff16ca23df/404_2022_6891_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3379/10808154/41ff16ca23df/404_2022_6891_Fig1_HTML.jpg

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本文引用的文献

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2
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Arch Gynecol Obstet. 2022 Jan;305(1):11-18. doi: 10.1007/s00404-021-06090-y. Epub 2021 May 11.
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Cervical ripening in prolonged pregnancies by silicone double balloon catheter versus vaginal dinoprostone slow release system: The MAGPOP randomised controlled trial.
硅胶双球囊导管与阴道地诺前列酮缓慢释放系统在延长妊娠中的宫颈成熟作用：MAGPOP 随机对照试验。
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Induction of labour in mid-trimester pregnancy using double-balloon catheter placement within 12 h versus within 12-24 h.在妊娠中期使用双球囊导管在 12 小时内与在 12-24 小时内放置诱导分娩。
BMC Pregnancy Childbirth. 2021 Jan 6;21(1):17. doi: 10.1186/s12884-020-03513-7.
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Effectiveness of Dinoprostone and Cook's Balloon for Labor Induction in Primipara Women at Term.足月初产妇应用地诺前列酮与库克导尿管促宫颈成熟引产的效果。
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Cervical ripening: Why we do what we do.宫颈成熟化：我们为什么这样做。
Semin Perinatol. 2020 Mar;44(2):151216. doi: 10.1016/j.semperi.2019.151216. Epub 2019 Nov 23.
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