Sadeghi H, Williams K, Klein C
E. A. Doisy Department of Biochemistry, St. Louis University Medical School, Missouri 63104.
J Biol Chem. 1987 Dec 5;262(34):16294-9.
Antigen 117 is involved in the process of intercellular cohesion in Dictyostelium discoideum (Brodie, C., Klein, C., and Swierkosz, J. Cell 32, 1115-1123 (1983]. The antigen was shown to arise from a 62,000-64,000-dalton precursor. The mature antigen consists of two forms of molecular weights, 69,000 and 72,000. These forms are glycosylated, phosphorylated, acylated, and sulfated. Developmental changes in the cellular and cell surface levels of the antigen reflect changes in its rate of synthesis. All aggregating cells express antigen 117 on their surfaces. Antigen 117 then disappears from the surface of all cells when tip formation occurs. The antigen is re-expressed briefly again on cells undergoing culmination.
抗原117参与盘基网柄菌细胞间黏附过程（布罗迪，C.，克莱因，C.，以及斯维尔科斯，J.《细胞》32卷，1115 - 1123页（1983年））。该抗原由一种62,000 - 64,000道尔顿的前体产生。成熟抗原由分子量分别为69,000和72,000的两种形式组成。这些形式进行了糖基化、磷酸化、酰化和硫酸化修饰。抗原在细胞内和细胞表面水平的发育变化反映了其合成速率的变化。所有聚集细胞在其表面表达抗原117。当形成菌柄时，抗原117从所有细胞表面消失。该抗原在进行子实体形成的细胞上会再次短暂表达。
