Arnouk Serena, Huynh Quy, Saric Muhamed, Papadopoulos John
Department of Pharmacy, NYU Langone Health, New York, NY, USA.
Leon H Charney Division of Cardiology, NYU Langone Health, New York, NY, USA.
J Pharm Pract. 2024 Apr;37(2):509-512. doi: 10.1177/08971900231158935. Epub 2023 Feb 19.
Ultrasound enhancing agents (UEAs) are medications that enable clear visualization of ultrasound images. While large studies have demonstrated the safety of these agents, case reports of life-threatening reactions temporally associated with their use have been published and reported to the Food and Drug Administration. Current literature describes the most serious adverse reactions due to UEAs to be allergic in nature; however, embolic phenomena may play a role as well. Here, we report a case of unexplained cardiac arrest following the administration of sulfur hexafluoride (Lumason) in an adult inpatient undergoing echocardiography where resuscitative efforts were ultimately unsuccessful, and review possible mechanisms of cardiac arrest based on prior published literature.
超声增强剂（UEAs）是能够使超声图像清晰可视化的药物。虽然大型研究已证明这些药物的安全性，但与它们的使用在时间上相关的危及生命反应的病例报告已发表并上报给美国食品药品监督管理局。当前文献描述，由UEAs引起的最严重不良反应本质上是过敏反应；然而，栓塞现象也可能起作用。在此，我们报告一例成年住院患者在接受超声心动图检查时注射六氟化硫（Lumason）后发生不明原因心脏骤停的病例，该患者复苏最终未成功，并根据既往发表的文献回顾心脏骤停的可能机制。
