Alves Cátia G, Lima-Sousa Rita, Melo Bruna L, Ferreira Paula, Moreira André F, Correia Ilídio J, Melo-Diogo Duarte de
CICS-UBI - Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior, Avenida Infante D Henrique, Covilhã, 6200-506, Portugal.
CIEPQPF - Departamento de Engenharia Química, Universidade de Coimbra, Rua Sílvio Lima, Coimbra, 3030-790, Portugal.
Nanomedicine (Lond). 2022 Nov;17(27):2057-2072. doi: 10.2217/nnm-2022-0218. Epub 2023 Feb 21.
To address the limitations of IR780 by preparing hydrophilic polymer-IR780 conjugates and to employ these conjugates in the assembly of nanoparticles (NPs) intended for cancer photothermal therapy. The cyclohexenyl ring of IR780 was conjugated for the first time with thiol-terminated poly(2-ethyl-2-oxazoline) (PEtOx). This novel poly(2-ethyl-2-oxazoline)-IR780 (PEtOx-IR) conjugate was combined with D-α-tocopheryl succinate (TOS), leading to the assembly of mixed NPs (PEtOx-IR/TOS NPs). PEtOx-IR/TOS NPs displayed optimal colloidal stability as well as cytocompatibility in healthy cells at doses within the therapeutic range. In turn, the combination of PEtOx-IR/TOS NPs and near-infrared light reduced heterotypic breast cancer spheroid viability to just 15%. PEtOx-IR/TOS NPs are promising agents for breast cancer photothermal therapy.
通过制备亲水性聚合物 - IR780 共轭物来解决 IR780 的局限性，并将这些共轭物用于组装用于癌症光热治疗的纳米颗粒（NPs）。IR780 的环己烯基环首次与硫醇封端的聚（2 - 乙基 - 2 - 恶唑啉）（PEtOx）共轭。这种新型的聚（2 - 乙基 - 2 - 恶唑啉）-IR780（PEtOx - IR）共轭物与琥珀酸 D-α-生育酚酯（TOS）结合，导致混合纳米颗粒（PEtOx - IR/TOS NPs）的组装。在治疗范围内的剂量下，PEtOx - IR/TOS NPs 在健康细胞中表现出最佳的胶体稳定性和细胞相容性。反过来，PEtOx - IR/TOS NPs 与近红外光的组合将异型乳腺癌球体活力降低至仅 15%。PEtOx - IR/TOS NPs 是用于乳腺癌光热治疗的有前景的药物。
