Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.
Key Laboratory of Oral Diseases Research of Anhui Province, Stomatological Hospital & College, Anhui Medical University, China.
Dent Mater. 2018 Dec;34(12):e344-e352. doi: 10.1016/j.dental.2018.10.007. Epub 2018 Oct 25.
To evaluate the remineralising effect of the adjunctive application of 38% silver diamine fluoride (SDF) solution and 5% sodium fluoride (NaF) varnish on artificial enamel caries lesions.
Forty-eight demineralised enamel specimens were allocated into four groups. Group 1 received 38% SDF and 5% NaF; Group 2 received 38% SDF; Group 3 received 5% NaF; and Group 4 received deionized water. After pH cycling, the surface morphology and fluoride content of the specimens were studied via scanning electron microscopy (SEM)/energy dispersive spectroscopy (EDS). The lesion depth and crystal characteristics were assessed using micro-computed tomography and X-ray diffraction (XRD) respectively. The crystallization reaction was performed by incubating hydroxyapatite powder with NaF or SDF for 48h. The precipitates were studied via transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS).
SEM demonstrated the destruction of the enamel surface in Group 4. EDS revealed that the mean fluoride weight percentage of Groups 1-4 were 1.28±0.15, 1.33±0.19, 1.03±0.09 and 0.87±0.04 respectively. The mean lesion depths of Groups 1-4 were 129±14μm, 131±16μm, 153±10μm and 181±21μm respectively. The addition of NaF to SDF did not reduce the lesion depths (p=0.779). XRD revealed that silver chloride formed as a main product in Groups 1 and 2. Meanwhile, TEM analysis indicated that silver nanoparticles were incorporated into hydroxyapatite crystal in SDF-treated hydroxyapatite. XPS spectra suggested that the chemical state of the silver was metallic.
The adjunctive application of SDF and NaF varnish had a similar remineralising effect to that of SDF on enamel caries.
评估 38% 氟化银（SDF）溶液和 5%氟化钠（NaF）涂料联合应用对人工釉质龋损的再矿化效果。
将 48 个脱矿釉质标本分为 4 组。第 1 组接受 38%SDF 和 5%NaF；第 2 组接受 38%SDF；第 3 组接受 5%NaF；第 4 组接受去离子水。pH 循环后，通过扫描电子显微镜（SEM）/能谱（EDS）研究标本的表面形态和氟含量。使用微计算机断层扫描和 X 射线衍射（XRD）分别评估病变深度和晶体特征。通过将羟基磷灰石粉末与 NaF 或 SDF 孵育 48h 进行结晶反应。通过透射电子显微镜（TEM）和 X 射线光电子能谱（XPS）研究沉淀物。
SEM 显示第 4 组釉质表面破坏。EDS 显示，1-4 组的平均氟重量百分比分别为 1.28±0.15、1.33±0.19、1.03±0.09 和 0.87±0.04。1-4 组的平均病变深度分别为 129±14μm、131±16μm、153±10μm和 181±21μm。SDF 中加入 NaF 并未降低病变深度（p=0.779）。XRD 显示第 1 组和第 2 组形成主要产物氯化银。同时，TEM 分析表明，SDF 处理的羟基磷灰石中银纳米颗粒掺入羟基磷灰石晶体。XPS 谱表明银的化学状态为金属态。
SDF 和 NaF 涂料联合应用对釉质龋具有与 SDF 相似的再矿化作用。
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