Miyata Eye Hospital, Miyazaki, Japan.
Department of Ophthalmology, School of Medicine, Kitasato University, Sagamihara, Japan.
Ocul Immunol Inflamm. 2023 Sep;31(7):1416-1424. doi: 10.1080/09273948.2023.2175697. Epub 2023 Feb 21.
Human T-cell leukemia virus type 1 (HTLV-1) is a human retrovirus that causes T-cell malignant diseases (adult T-cell leukemia/lymphoma) and HTLV-1-related non-malignant inflammatory diseases, such as HTLV-1 uveitis. Although the symptoms and signs of HTLV-1 uveitis are nonspecific, intermediate uveitis with various degrees of vitreous opacity is the most common clinical presentation. It can occur in one or both eyes and its onset is acute or subacute. Intraocular inflammation can be managed with topical and/or systemic corticosteroids; however, recurrence of uveitis is common. The visual prognosis is generally favorable, but a certain proportion of patients have a poor visual prognosis. Systemic complications of patients with HTLV-1 uveitis include Graves' disease and HTLV-1-associated myelopathy/tropical spastic paraparesis. This review describes the clinical characteristics, diagnosis, ocular manifestations, management, and immunopathogenic mechanisms of HTLV-1 uveitis.
人类 T 细胞白血病病毒 1 型（HTLV-1）是一种人类逆转录病毒，可引起 T 细胞恶性疾病（成人 T 细胞白血病/淋巴瘤）和 HTLV-1 相关的非恶性炎症性疾病，如 HTLV-1 葡萄膜炎。尽管 HTLV-1 葡萄膜炎的症状和体征是非特异性的，但伴有不同程度玻璃体混浊的中间葡萄膜炎是最常见的临床表现。它可发生于单眼或双眼，起病急或亚急性。眼内炎症可通过局部和/或全身皮质类固醇治疗；然而，葡萄膜炎复发很常见。葡萄膜炎的预后一般较好，但有一定比例的患者预后较差。HTLV-1 葡萄膜炎患者的全身并发症包括格雷夫斯病和 HTLV-1 相关脊髓病/热带痉挛性截瘫。本文综述了 HTLV-1 葡萄膜炎的临床特征、诊断、眼部表现、治疗和免疫发病机制。
