硫喷妥钠注射液在一次性塑料注射器中的化学稳定性。

Chemical stability of thiopental sodium injection in disposable plastic syringes.

作者信息

Das Gupta V, Gardner S N, Jolowsky C M, Newcomer D R, Stewart K R

机构信息

Department of Pharmaceutics, University of Houston, TX 77030.

出版信息

J Clin Pharm Ther. 1987 Oct;12(5):339-42. doi: 10.1111/j.1365-2710.1987.tb00546.x.

DOI:10.1111/j.1365-2710.1987.tb00546.x

PMID:3680403

Abstract

The chemical stability of thiopental sodium injection (2.5%) when stored at 25 degrees and 5 degrees in disposable plastic syringes of two manufacturers (Monoject and Becton Dickenson and Co.) has been studied using the USP-NF method. The injection appeared to be stable for five days at 25 degrees and 45 days at 5 degrees with a loss in potency of less than 7%. The thiopental sodium did not adsorb on the syringes. The pH values and the physical appearance did not change. An additional peak was obtained in the chromatogram from both the freshly prepared and the assay solution probably due to an impurity in the powder.

摘要

使用美国药典-国家处方集（USP-NF）方法，研究了硫喷妥钠注射液（2.5%）在25摄氏度和5摄氏度下，分别储存在两个制造商（Monoject和百特公司）生产的一次性塑料注射器中的化学稳定性。该注射液在25摄氏度下似乎可稳定保存5天，在5摄氏度下可稳定保存45天，效力损失小于7%。硫喷妥钠未吸附在注射器上。pH值和外观均未改变。新鲜配制溶液和测定溶液的色谱图中均出现了一个额外的峰，这可能是由于粉末中的杂质所致。