Chernin E L, Stewart J T, Smiler B
Department of Pharmaceutical Services, Sarasota Memorial Hospital, FL 34239, USA.
Am J Health Syst Pharm. 1996 Jul 1;53(13):1576-9. doi: 10.1093/ajhp/53.13.1576.
The stability of thiopental sodium and propofol in an admixture stored in polypropylene syringes at room temperature and under refrigeration was studied. Propofol injection 10 mg/ mL and thiopental sodium 25 mg/mL were mixed to final concentrations of 5 and 12.5 mg/mL, respectively. The admixture was put into 60-mL polypropylene syringes, and two syringes were stored at 23 degrees C and two at 4 degrees C. For solutions stored at 23 degrees C, samples were taken at 0, 4, 8, 24, 48, 72, 120, 168, 216, 240, and 264 hours, and for samples stored at 4 degrees C, samples were taken at 0, 4, 8, 24, 48, 72, 120, 168, 216, and 312 hours. Drug concentrations were determined by high-performance liquid chromatography. Thiopental sodium and propofol retained > 90% of their initial concentrations for up to 312 hours at 4 degrees C. At 23 degrees C, > 90% of the initial concentration was retained by propofol for up to 120 hours and by thiopental sodium for up to 240 hours. No visual changes or significant change in pH occurred in any sample. When mixed and stored in polypropylene syringes, propofol 5 mg/mL and thiopental sodium 12.5 mg/mL were stable for up to 312 hours at 4 degrees C and for up to 120 hours at 23 degrees C.
研究了硫喷妥钠和丙泊酚在室温及冷藏条件下于聚丙烯注射器中混合液的稳定性。将10mg/mL的丙泊酚注射液和25mg/mL的硫喷妥钠混合，最终浓度分别为5mg/mL和12.5mg/mL。将混合液装入60mL聚丙烯注射器中，两个注射器于23℃储存，两个于4℃储存。对于在23℃储存的溶液，在0、4、8、24、48、72、120、168、216、240和264小时取样；对于在4℃储存的样品，在0、4、8、24、48、72、120、168、216和312小时取样。通过高效液相色谱法测定药物浓度。硫喷妥钠和丙泊酚在4℃下长达312小时保持其初始浓度的>90%。在23℃时，丙泊酚长达120小时、硫喷妥钠长达240小时保持>90%的初始浓度。任何样品均未出现外观变化或pH值的显著变化。当在聚丙烯注射器中混合并储存时，5mg/mL的丙泊酚和12.5mg/mL的硫喷妥钠在4℃下长达312小时稳定，在23℃下长达120小时稳定。
