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室内低水平甲苯暴露对工作记忆编码期间神经网络改变的影响。

Effects of indoor exposure to low level toluene on neural network alterations during working memory encoding.

机构信息

General Medicine Department, Tianjin Medical University General Hospital, Tianjin, 300052, China.

General Medicine Department, Tianjin Medical University General Hospital, Tianjin, 300052, China; Tianjin Medical University, Tianjin, 300070, China.

出版信息

Chemosphere. 2023 Apr;321:138153. doi: 10.1016/j.chemosphere.2023.138153. Epub 2023 Feb 16.

DOI:10.1016/j.chemosphere.2023.138153
PMID:36804498
Abstract

OBJECTIVE

While high concentrations of toluene are known to affect multiple human organ systems, research concerning the influence of immediate, short-term exposure to toluene indoors and at low concentrations is scarce. Here, we studied effects of indoor toluene exposure on neural network alterations during working memory (WM) encoding.

METHODS

A total of 23 healthy college students were recruited. All participants were situated in a closed environmental chamber with a full fresh air system. Each participant was subjected to four exposure experiments with different toluene concentrations (0, 17.5, 35, and 70 ppb, named Group A, B, C and D, respectively), with at least one week between each experiment. WM Behavioral and 19-channel electroencephalogram (EEG) recordings in a pre-set environmental chamber were conducted simultaneously during each toluene exposure experiment. Neural networks relevant to WM encoding were visualized analyzing the obtained data.

RESULTS

  1. No significant difference in WM behavioral performance among the four groups was found. However, a significant increase in whole brain neural network functional connectivity was noted, especially in the frontal region. 2. An outflow directional transfer function (DTF) revealed higher frontal region values among Group D (the 70 ppb group) as compared to Group A, B and C (the0, 17.5 ppb and 35 ppb groups, respectively), although no differences in frontal region DTF values among the four groups were noted. 3. The DTF, DTF, DTF, DTF, DTF, DTF, DTF, DTF and DTF values of Group D were found to be higher as compared to those of Group A and B. Furthermore, DTF and DTF values of Group C were higher as compared to those of Group A. The DTF values of Group D were higher as compared to those of the Group C.

CONCLUSION

Short-term toluene exposure significantly influences neural networks during cognitive processes such as WM encoding, even at low concentration.

摘要

目的

虽然已知高浓度的甲苯会影响多个人体器官系统，但有关室内和低浓度下立即、短期接触甲苯对人体的影响的研究却很少。在这里，我们研究了室内甲苯暴露对工作记忆（WM）编码过程中神经网络改变的影响。

方法

共招募了 23 名健康大学生。所有参与者均处于带全新风系统的封闭环境舱内。每位参与者分别接受了四种不同甲苯浓度（0、17.5、35 和 70 ppb，分别命名为 A、B、C 和 D 组）的暴露实验，每组实验之间至少间隔一周。在每次甲苯暴露实验中，同时进行 WM 行为和 19 通道脑电图（EEG）记录。通过分析获得的数据，可视化与 WM 编码相关的神经网络。

结果

  1. 四组间 WM 行为表现无显著差异。然而，观察到全脑神经网络功能连接显著增加，尤其是在前额区域。2. 输出方向转移函数（DTF）显示，与 A、B 和 C 组（分别为 0、17.5 和 35 ppb 组）相比，D 组（70 ppb 组）的前额区域 DTF 值更高，尽管四组间前额区域 DTF 值无差异。3. 与 A 组和 B 组相比，D 组的 DTF、DTF、DTF、DTF、DTF、DTF、DTF、DTF 和 DTF 值更高。此外，C 组的 DTF 和 DTF 值高于 A 组。D 组的 DTF 值高于 C 组。

结论

即使在低浓度下，短期甲苯暴露也会显著影响认知过程（如 WM 编码）期间的神经网络。

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