Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America; Department of Maternal and Child Health, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Prev Med. 2023 Apr;169:107455. doi: 10.1016/j.ypmed.2023.107455. Epub 2023 Feb 19.
Violence victimization has been associated with low-grade inflammation. Lesbian, Gay, and Bisexual (LGB) individuals are at greater risk for victimization in childhood and young adulthood compared to heterosexuals. Moreover, the intersection of LGB identity with gender, race/ethnicity, and educational attainment may be differentially associated with victimization rates. However, no previous study has examined the role of cumulative life-course victimization during childhood and young adulthood in the association between 1) LGB identity and low-grade inflammation during the transition to midlife, and 2) intersection of LGB identity with gender, race/ethnicity, and educational attainment and low-grade inflammation during the transition to midlife. We utilized multi-wave data from a national sample of adults entering midlife in the United States- the National Longitudinal Study of Adolescent to Adult Health (Add Health; n = 4573) - and tested four bootstrapped mediation models. Results indicate LGB identity, LGB and White, and LGB and Black identities were indirectly associated with low-grade inflammation during the transition to midlife via higher levels of cumulative life-course victimization. Moreover, among LGB adults, the association between 1) less than college education and 2) some college education, and low-grade inflammation was mediated by cumulative life-course victimization. For LGB females, there was a direct association between identity and low-grade inflammation and this association was mediated by cumulative life-course victimization . Reducing accumulation of victimization could be critical for preventing biological dysregulation and disease onset among LGB individuals, particularly for those with multiple marginalized identities.
暴力受害与低度炎症有关。与异性恋者相比，女同性恋、男同性恋和双性恋（LGB）个体在儿童和青年时期更有可能成为受害对象。此外，LGB 身份与性别、种族/民族和教育程度的交叉可能与受害率存在差异相关。然而，以前没有研究检查过童年和青年时期的累积生活经历受害在 LGB 身份与中年过渡期间低度炎症之间的关系，以及 LGB 身份与性别、种族/民族和教育程度的交叉与中年过渡期间低度炎症之间的关系。我们利用来自美国进入中年的成年人的全国性样本的多波数据-青少年到成人健康的国家纵向研究（Add Health；n=4573）-并测试了四个 bootstrap 中介模型。结果表明，LGB 身份、LGB 和白人和 LGB 和黑人身份通过更高水平的累积生活经历受害，与中年过渡期间的低度炎症间接相关。此外，在 LGB 成年人中，1）未接受过大学教育和 2）接受过一些大学教育与低度炎症之间的关联是通过累积生活经历受害来介导的。对于 LGB 女性，身份与低度炎症之间存在直接关联，这种关联是通过累积生活经历受害来介导的。减少受害的积累对于预防 LGB 个体的生物失调和疾病发作可能至关重要，特别是对于那些具有多种边缘化身份的个体。
