Sakata-Yanagimoto Mamiko, Makishima Kenichi, Suehara Yasuhito
Dept. of Hematology, Faculty of Medicine, University of Tsukuba.
Gan To Kagaku Ryoho. 2023 Feb;50(2):129-133.
In the hematopoietic system of healthy individuals, a phenomenon called clonal hematopoiesis, in which cells acquired somatic mutations are replaced with aging, has been discovered. The frequency of clonal hematopoiesis is higher in patients with solid tumors, than normal individuals. In addition, it is thought that infiltration of inflammatory cells with somatic mutations into cancer tissues may change the tumor microenvironment. Since clonal hematopoiesis is often found incidentally in gene panel testing of solid cancer tissues, it is of great significance to have an insight into clonal hematopoiesis in the medical care of solid cancer patients. In this paper, we describe the general concept of clonal hematopoiesis, the frequency of clonal hematopoiesis in patients with solid tumors, the characteristics of the clinical course in patients with clonal hematopoiesis, and microscopic observations of solid tumors in mouse models of clonal hematopoiesis.
在健康个体的造血系统中，已发现一种称为克隆性造血的现象，即随着衰老，获得体细胞突变的细胞会被更替。实体瘤患者中克隆性造血的频率高于正常个体。此外，人们认为带有体细胞突变的炎性细胞浸润到癌组织中可能会改变肿瘤微环境。由于克隆性造血在实体癌组织的基因panel检测中经常偶然发现，因此深入了解克隆性造血在实体癌患者的医疗护理中具有重要意义。在本文中，我们描述了克隆性造血的一般概念、实体瘤患者中克隆性造血的频率、克隆性造血患者的临床病程特征以及克隆性造血小鼠模型中实体瘤的显微镜观察结果。
