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调查杀草天然产物 (+)-Cornexistin 的简化类似物。

Investigations into Simplified Analogues of the Herbicidal Natural Product (+)-Cornexistin.

机构信息

Institute of Organic Chemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80-82, 6020, Innsbruck, Austria.

Research & Development, Weed Control Bayer AG, Crop Science Division, Industriepark Höchst, 65926, Frankfurt am Main, Germany.

出版信息

Chemistry. 2023 Jul 11;29(39):e202300199. doi: 10.1002/chem.202300199. Epub 2023 May 23.

DOI:10.1002/chem.202300199
PMID:36807428
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7614749/
Abstract

We report the design, synthesis and biological evaluation of simplified analogues of the herbicidal natural product (+)-cornexistin. Guided by an X-Ray co-crystal structure of cornexistin bound to transketolase from Zea mays, we attempted to identify the key interactions that are necessary for cornexistin to maintain its herbicidal profile. This resulted in the preparation of three novel analogues investigating the importance of substituents that are located on the nine-membered ring of cornexistin. One analogue maintained a good level of biological activity and could provide researchers insights in how to further optimize the structure of cornexistin for commercialization in the future.

摘要

我们报告了除草剂天然产物（+）-玉米素的简化类似物的设计、合成和生物评价。根据（+）-玉米素与玉米转酮醇酶的 X 射线共晶结构，我们试图确定维持其除草特性所必需的关键相互作用。这导致了三种新型类似物的制备，研究了位于玉米素的九元环上的取代基的重要性。一种类似物保持了良好的生物活性水平，这可为研究人员提供如何进一步优化玉米素的结构以在未来实现商业化的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3901/10947101/a2a6c858203f/CHEM-29-0-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3901/10947101/3242897bb6ea/CHEM-29-0-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3901/10947101/94071f07cd10/CHEM-29-0-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3901/10947101/7ffa48092810/CHEM-29-0-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3901/10947101/40af8870abd8/CHEM-29-0-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3901/10947101/930659d5357c/CHEM-29-0-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3901/10947101/4a3296a31de2/CHEM-29-0-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3901/10947101/a2a6c858203f/CHEM-29-0-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3901/10947101/3242897bb6ea/CHEM-29-0-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3901/10947101/94071f07cd10/CHEM-29-0-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3901/10947101/7ffa48092810/CHEM-29-0-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3901/10947101/40af8870abd8/CHEM-29-0-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3901/10947101/930659d5357c/CHEM-29-0-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3901/10947101/4a3296a31de2/CHEM-29-0-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3901/10947101/a2a6c858203f/CHEM-29-0-g003.jpg

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