Research Laboratory Education, Motricité, Sport Et Santé, EM2S, LR19JS01, High Institute of Sport and Physical Education of Sfax, University of Sfax, Airport Road, Km 3.5, 3000, Sfax, Tunisia.
Research Laboratory, Molecular Bases of Human Pathology, LR19ES13, Faculty of Medicine of Sfax, University of Sfax, Sfax, Tunisia.
Biol Trace Elem Res. 2023 Nov;201(11):5162-5168. doi: 10.1007/s12011-023-03603-5. Epub 2023 Feb 18.
Proprioception is essential to several conscious and unconscious sensations and automatic control of movement in daily life activities. Iron deficiency anemia (IDA) may alter proprioception as it could induce fatigue, and affect neural processes such as myelination, and neurotransmitters synthesis and degradation. This study aimed to explore the effect of IDA on proprioception in adult women. Thirty adult women with IDA and 30 controls participated in this study. The weight discrimination test was performed to assess proprioceptive acuity. Attentional capacity and fatigue were evaluated, too. Women with IDA had a significantly (P < 0.001) lower ability to discriminate weights compared to controls in the two difficult increments, and for the second easy weight (P < 0.01). For the heaviest weight, no significant difference was found. Attentional capacity and fatigue values were significantly (P < 0.001) higher in patients with IDA compared to controls. Moreover, moderate positive correlations between the representative proprioceptive acuity values and Hb (r = 0.68) and ferritin (r = 0.69) concentrations were found. Moderate negative correlations were found between the proprioceptive acuity values and general (r = - 0.52), physical (r = - 0.65) and mental (r = - 0.46) fatigue scores, and attentional capacity (r = - 0.52). Women with IDA had impaired proprioception compared to their healthy peers. This impairment may be related to neurological deficits due to the disruption of iron bioavailability in IDA. In addition, fatigue resulting from IDA due to the poor muscle oxygenation could also explain the proprioceptive acuity decrease in women suffering from IDA.
本体感觉对于日常生活活动中的几种有意识和无意识感觉以及运动的自动控制至关重要。缺铁性贫血 (IDA) 可能会改变本体感觉，因为它会引起疲劳，并影响神经过程，如髓鞘形成以及神经递质的合成和降解。本研究旨在探讨 IDA 对成年女性本体感觉的影响。30 名患有 IDA 的成年女性和 30 名对照者参与了这项研究。采用重量辨别测试评估本体感觉锐度。还评估了注意力能力和疲劳程度。与对照组相比，IDA 女性在两个较难的增量和第二个较易的重量（P<0.01）上辨别重量的能力明显（P<0.001）较低。对于最重的重量，没有发现显著差异。与对照组相比，IDA 患者的注意力能力和疲劳值明显（P<0.001）更高。此外，代表本体感觉锐度值与 Hb（r=0.68）和铁蛋白（r=0.69）浓度之间存在中度正相关。本体感觉锐度值与一般（r=-0.52）、身体（r=-0.65）和心理（r=-0.46）疲劳评分以及注意力能力（r=-0.52）之间存在中度负相关。与健康同龄人相比，IDA 女性的本体感觉受损。这种损伤可能与 IDA 中由于铁生物利用度的破坏导致的神经功能缺陷有关。此外，由于肌肉氧合不良导致的 IDA 引起的疲劳也可能解释了患有 IDA 的女性本体感觉锐度下降。
