Artificial intelligence chatbots will revolutionize how cancer patients access information: ChatGPT represents a paradigm-shift.

On November 30, 2022, OpenAI enabled public access to ChatGPT, a next-generation artificial intelligence with a highly sophisticated ability to write, solve coding issues, and answer questions. This communication draws attention to the prospect that ChatGPT and its successors will become important virtual assistants to patients and health-care providers. In our assessments, ranging from answering basic fact-based questions to responding to complex clinical questions, ChatGPT demonstrated a remarkable ability to formulate interpretable responses, which appeared to minimize the likelihood of alarm compared with Google's feature snippet. Arguably, the ChatGPT use case presents an urgent need for regulators and health-care professionals to be involved in developing standards for minimum quality and to raise patient awareness of current limitations of emerging artificial intelligence assistants. This commentary aims to raise awareness at the tipping point of a paradigm shift.