The Microbiome Center, Huck Institutes of the Life Sciences, Pennsylvania State University, PA, USA.
Microbiology (Reading). 2023 Feb;169(2). doi: 10.1099/mic.0.001302.
The mutualistic symbiosis between the Hawaiian bobtail squid and the marine bacterium is a powerful experimental system for determining how intercellular interactions impact animal-bacterial associations. In nature, this symbiosis features multiple strains of within each adult animal, which indicates that different strains initially colonize each squid. Various studies have demonstrated that certain strains of possess a type-VI secretion system (T6SS), which can inhibit other strains from establishing symbiosis within the same host habitat. The T6SS is a bacterial melee weapon that enables a cell to kill adjacent cells by translocating toxic effectors via a lancet-like apparatus. This review describes the progress that has been made in understanding the factors that govern the structure and expression of the T6SS in and its effect on the symbiosis.
夏威夷短尾乌贼和海洋细菌之间的互利共生关系是一个强大的实验系统，可以确定细胞间相互作用如何影响动物-细菌的联系。在自然界中，这种共生关系在每个成年动物体内都有多个 菌株，这表明不同的菌株最初会定植每个乌贼。多项研究表明，某些 菌株拥有一种类型六分泌系统（T6SS），它可以抑制其他菌株在同一宿主栖息地建立共生关系。T6SS 是一种细菌近战武器，它可以通过一种类似矛头的装置将毒性效应器转移到相邻的细胞中，从而使一个细胞杀死相邻的细胞。这篇综述描述了在理解控制 T6SS 的结构和表达的因素及其对共生关系的影响方面所取得的进展。
