基因多态性及其与中国人群慢性阻塞性肺疾病易感性的关系。
gene polymorphisms and their relation to chronic obstructive pulmonary disease susceptibility in the Chinese population.
机构信息
Department of General Practice, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, 570311, China.
Department of Pulmonary & Critical Care Medicine, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, 570311, China.
出版信息
Biomark Med. 2022 Dec;16(17):1229-1237. doi: 10.2217/bmm-2022-0342. Epub 2023 Feb 21.
This work was designed to explore the correlation between polymorphisms and chronic obstructive pulmonary disease (COPD) susceptibility. Agena MassARRAY was used to genotype five SNPs of in 498 patients with COPD and 498 controls. Genetic models and haplotype analysis were used to assess the associations between SNPs and COPD risk. Rs6689306 and rs4845625 increase the risk of COPD. Rs4537545, rs4129267 and rs2228145 were related to a decreased risk of COPD in different subgroups. Haplotype analysis revealed that GTCTC, GCCCA and GCTCA contributed to a reduced risk of COPD after adjustment. polymorphisms are significantly associated with COPD susceptibility.
本研究旨在探讨多态性与慢性阻塞性肺疾病（COPD）易感性之间的相关性。采用 Agena MassARRAY 对 498 例 COPD 患者和 498 例对照者的 5 个 SNPs 进行基因分型。采用遗传模型和单倍型分析评估 SNPs 与 COPD 风险之间的关联。rs6689306 和 rs4845625 增加 COPD 风险。rs4537545、rs4129267 和 rs2228145 在不同亚组中与 COPD 风险降低相关。单倍型分析显示，GTCTC、GCCCA 和 GCTCA 在调整后有助于降低 COPD 的发病风险。多态性与 COPD 易感性显著相关。
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