MIR2113 和 MIR129-LEP 中的遗传变异与中国汉族人群 COPD 的易感性相关。
Genetic variants in MIR2113 and MIR129-LEP are associated with the susceptibility of COPD in the Chinese Han population.
机构信息
COPD Laboratory of Clinical Research Center, Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine, Urumqi, Xinjiang, 830099, PR China.
COPD Laboratory of Clinical Research Center, Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine, Urumqi, Xinjiang, 830099, PR China.
出版信息
Pulm Pharmacol Ther. 2020 Oct;64:101945. doi: 10.1016/j.pupt.2020.101945. Epub 2020 Sep 12.
BACKGROUND
Chronic obstructive pulmonary disease (COPD) is the result of interaction between genetic and environmental factors. In this study, we aimed to explore whether MIR2113 and MIR129-LEP polymorphisms confer susceptibility to COPD.
METHODS
We selected five polymorphisms of two genes (MIR2113: rs2505059 and rs9320913; MIR129-LEP: rs7778167, rs791595 and rs4731420) based on previous studies and genotyped 629 samples, which included 315 COPD patients and 314 controls with Agena MassARRAY platform. The association of MIR2113 and MIR129-LEP polymorphisms with COPD risk was conducted with logistic regression by calculating odd ratios (OR) and 95% confidence intervals (CI).
RESULTS
MIR2113 rs2505059 was remarkably linked with a decreased susceptibility of COPD in five genetic models, whereas MIR2113 rs9320913, MIR129-LEP rs791595 and MIR129-LEP rs4731420 could enhance the susceptibility of COPD in the Chinese Han population (P < 0.05). Stratified analysis revealed that the influences of genetic variants on COPD risk were dependent on age, sex, Body mass index or smoking status (P < 0.05). Haplotype analysis showed that AC haplotype significant increased the susceptibility of COPD.
CONCLUSION
It suggested that polymorphisms of MIR2113 and MIR129-LEP might be linked with the susceptibility of COPD among the Chinese Han population.
背景
慢性阻塞性肺疾病（COPD）是遗传和环境因素相互作用的结果。本研究旨在探讨 MIR2113 和 MIR129-LEP 多态性是否与 COPD 易感性相关。
方法
我们根据既往研究选择了两个基因的五个多态性（MIR2113：rs2505059 和 rs9320913；MIR129-LEP：rs7778167、rs791595 和 rs4731420），并使用 Agena MassARRAY 平台对 629 例样本（315 例 COPD 患者和 314 例对照）进行基因分型。使用逻辑回归计算比值比（OR）和 95%置信区间（CI），分析 MIR2113 和 MIR129-LEP 多态性与 COPD 风险的关系。
结果
MIR2113 rs2505059 在五种遗传模型中与 COPD 易感性降低显著相关，而 MIR2113 rs9320913、MIR129-LEP rs791595 和 MIR129-LEP rs4731420 则可增加中国汉族人群 COPD 的易感性（P<0.05）。分层分析显示，遗传变异对 COPD 风险的影响依赖于年龄、性别、体重指数或吸烟状态（P<0.05）。单倍型分析显示 AC 单倍型显著增加了 COPD 的易感性。
结论
MIR2113 和 MIR129-LEP 多态性可能与中国汉族人群 COPD 的易感性相关。
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