Frank R M
J Dent Res. 1979 Mar;58(Spec Issue B):684-94. doi: 10.1177/002203457905800220011.
Important progress has been made relative to the growth, structure and function of enamel. Better understanding of the epithelial mesenchymal interactions during odontogenesis has been gained through tissue culture, and the predominant role of the dental papilla has been established. Differences between rodent and human amelogenesis have been demonstrated. With radioautography and cytochemistry, a significant amount of new information has been obtained on the metabolism of the ameloblasts, concerning the synthesis of proteins, glycoproteins and proteoglycans, as well as calcium transport. Numerous biochemical investigations have been devoted to developing and mature enamel matrix. The organic components of human adult enamel are mainly constituted of lipids and proteins, but further investigations are still needed to elucidate their precise nature. The so-called key-hole configuration of adult enamel can be questioned when amelogenesis is considered since the tissue does not develop in a prismatic head-tail fashion. The most important results have probably been obtained in the field of individual enamel apatite crystals shape and ultrastructure as well as in the description of the precise patterns of their carious dissolution which bears great similarities to the dissolution of synthetic apatites in acids.
在牙釉质的生长、结构和功能方面已取得重要进展。通过组织培养，人们对牙胚发生过程中的上皮-间充质相互作用有了更好的理解，并且确定了牙乳头的主要作用。已证明啮齿动物和人类釉质形成之间的差异。通过放射自显影术和细胞化学，已获得了大量关于成釉细胞代谢的新信息，涉及蛋白质、糖蛋白和蛋白聚糖的合成以及钙转运。许多生化研究致力于发育和成熟的牙釉质基质。人类成年牙釉质的有机成分主要由脂质和蛋白质组成，但仍需要进一步研究以阐明它们的确切性质。当考虑釉质形成时，成年牙釉质所谓的锁孔结构可能会受到质疑，因为该组织并非以棱柱形的头尾方式发育。最重要的成果可能是在单个牙釉质磷灰石晶体形状和超微结构领域以及对其龋齿溶解精确模式的描述方面取得的，这与合成磷灰石在酸中的溶解有很大相似之处。
