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慢性腹膜透析与血液透析新发病例患者的特征及1年生存率:一项为期11年的大型队列研究

Characteristics and 1-year survival of incident patients on chronic peritoneal dialysis compared with hemodialysis:a large 11-year cohort study.

作者信息

do Nascimento Lima Helbert, Nerbass Fabiana Baggio, Lugon Jocemir Ronaldo, Sesso Ricardo

机构信息

Department of Medicine, University of the Region of Joinville, Rua Rio do Sul, 270, Joinville, Santa Catarina, CEP 89202-201, Brazil.

Pró Rim Fundation, Joinville, Brazil.

出版信息

Int Urol Nephrol. 2023 Aug;55(8):2025-2033. doi: 10.1007/s11255-023-03489-1. Epub 2023 Feb 21.

Abstract

PURPOSE

Few studies have evaluated patients' characteristics and survival by dialysis modality in Brazil. We evaluated changes in dialysis modality and its survival in the country.

METHODS

This is a retrospective database of a cohort with incident chronic dialysis patients from Brazil. Patients' characteristics and one-year multivariate survival risk were assessed considering dialysis modality from 2011 to 2016 and 2017 to 2021. Survival analysis was also performed on a reduced sample after adjustment using propensity score matching.

RESULTS

Of the 8295 dialysis patients, 5.3% were on peritoneal dialysis (PD) and 94.7% on hemodialysis (HD). PD patients had higher BMI, schooling and the prevalence of elective dialysis starting in the first period than those on HD. In the second period, PD patients were predominantly women, non-white, from the Southeast region, and funded by the public health system, having more frequent elective dialysis starting and predialysis nephrologist follow-ups than those on HD. There was no difference in mortality comparing PD and HD (HR 0.67, 95% CI 0.39-2.42; and HR 1.17, 95% CI 0.63-2.16; first and second period, respectively). This non-significantly different survival between both dialysis methods was also found in the reduced matched sample. Higher age and non-elective dialysis initiation were associated with higher mortality. In the second period, the lack of predialysis nephrologist follow-up and living in the Southeast region increased the mortality risk.

CONCLUSION

Some sociodemographic factors have changed according to dialysis modality over the last decade in Brazil. The one-year survival of the two dialysis methods was comparable.

摘要

目的

在巴西,很少有研究按透析方式评估患者特征和生存率。我们评估了该国透析方式的变化及其生存率。

方法

这是一个来自巴西的慢性透析初诊患者队列的回顾性数据库。考虑2011年至2016年以及2017年至2021年的透析方式,评估了患者特征和一年多变量生存风险。还使用倾向评分匹配对调整后的减少样本进行了生存分析。

结果

在8295名透析患者中,5.3%接受腹膜透析(PD),94.7%接受血液透析(HD)。与接受血液透析的患者相比,腹膜透析患者在第一阶段的体重指数、受教育程度和择期透析患病率更高。在第二阶段,腹膜透析患者主要为女性、非白人、来自东南部地区,由公共卫生系统资助,与接受血液透析的患者相比,择期透析开始和透析前肾病医生随访更频繁。比较腹膜透析和血液透析的死亡率没有差异(风险比0.67,95%置信区间0.39 - 2.42;以及风险比1.17,95%置信区间0.63 - 2.16,分别为第一阶段和第二阶段)。在减少的匹配样本中也发现两种透析方法之间的生存差异无统计学意义。年龄较大和非择期开始透析与较高的死亡率相关。在第二阶段,透析前缺乏肾病医生随访以及居住在东南部地区会增加死亡风险。

结论

在过去十年中,巴西的一些社会人口学因素根据透析方式发生了变化。两种透析方法的一年生存率相当。

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